N.Y. Mets vs CH Cubs Picks: Game Day Showdown

As the Chicago Cubs prepare to host the New York Mets on September 25, 2025, at Wrigley Field in Chicago, IL, MLB fans and bettors alike are gearing up for an exciting showdown. The Cubs have shown mixed results recently, but with a strong home-field advantage and a promising lineup, they're ready to challenge the Mets. Our top pick for this game is the Cubs at a +1.5 spread, with a solid 65.2% probability of covering the spread. The pitching matchup will be crucial, as both teams have had varying success against right-handed pitchers. The TV broadcast will be on SNY. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. Join the action and explore more on our MLB picks page.

Our prediction model has been profitable in the last 10 games, especially in the point spread market with a remarkable hit rate. We project a close game with the Mets slightly ahead, but the Cubs' home advantage might just tip the scales. The predicted score leans towards the Mets, but don't underestimate the Cubs' potential to pull off a surprise. Tune in for what promises to be an intense battle between these two teams.