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Before the highly anticipated MLB matchup on September 14, 2025, between the Chicago White Sox and the Cleveland Guardians, fans and bettors alike are gearing up for an exciting showdown at Progressive Field in Cleveland, OH. This game promises to be a thrilling encounter as the Guardians, fresh off their recent victory, aim to maintain their momentum against the White Sox. On the betting front, the odds favor the Guardians with a moneyline of -170, while the White Sox stand at +143. The run line also shows the Guardians as favorites at -1.5 -110, indicating a tough challenge for the White Sox.
For bettors, understanding the betting lines can be crucial. The current odds reflect the Guardians' recent form and home advantage. However, the White Sox are known for their resilience and could surprise fans with an upset. The over/under is set at 8.5, with the UNDER favored at -120. If you're looking to make a smart bet, consider the Guardians' strong home performance and the White Sox's potential for an upset. Tune in to CHSN to catch the action live and make sure to check out our MLB odds page for the latest updates.
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![]() CHCC. Rea (R) 89-708% -166FanDuel | |||||||
WSHC. Cavalli (R) 65-9440% -130Caesars | |||||||
PHIA. Nola (R) 94-6553% -150BetMGM | |||||||
NYYW. Warren (R) 91-6854% -150BetMGM | |||||||
![]() TORS. Bieber (R) 91-6843% -184FanDuel | |||||||
MIAS. Alcantara (R) 77-8262% +120BetRivers | |||||||
BOSK. Harrison (L) 87-7246% -120Bet365 | |||||||
![]() CLES. Cecconi (R) 86-7310% -158FanDuel | |||||||
ATLJ. Wentz (L) 75-849% -156FanDuel | |||||||
MILQ. Priester (R) 96-6331% -165Caesars | |||||||
LAAK. Hendricks (R) 71-8891% +120BetRivers | |||||||
![]() SDY. Darvish (R) 87-7236% -136FanDuel | |||||||
SEAG. Kirby (R) 90-6940% -125BetMGM | |||||||
![]() ATHUndecided 75-84- -108FanDuel | |||||||
SFT. McDonald (R) 78-8118% -225BetMGM |
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