Pittsburgh Pirates vs Cincinnati Reds Picks

Get ready for an exciting MLB matchup as the Pittsburgh Pirates take on the Cincinnati Reds on September 25, 2025, at the Great American Ball Park in Cincinnati, OH. This game promises to be a thrilling encounter as both teams are eager to secure a win. The Pirates, known for their resilient gameplay, will face the Reds, who have a strong home record. Our picks suggest a close game, with the Reds slightly favored with a predicted score of Reds 4, Pirates 3. The Reds have a 58.8% chance of winning, according to our predictions, while the Pirates are not far behind with a 41.2% chance. This game will be broadcasted on Sportsnet PT, so don't miss out on the action. For those looking to place a wager, consider the Reds -1.5 on the point spread, though our model suggests a tighter game. Check out our MLB picks page for more insights. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. Our prediction model has been profitable in the last 10 games, winning 6 of them in the American Totals market, giving you a high EV and hit rate to consider for this matchup.