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As we gear up for the battle on September 23, 2025, between the Cleveland Guardians and the Detroit Tigers at Progressive Field in Cleveland, OH, MLB fans and bettors alike are buzzing with anticipation. This matchup is set to be broadcast on CLEG, providing a thrilling spectacle for those tuning in. The Guardians, playing at home, are eager to bounce back after their last encounter with the Tigers, where they fell short. Our prediction model gives the Tigers a slight edge with a 63.4% chance of winning, forecasting a close game with a predicted score of Detroit 4.08 to Cleveland 2.97.
The Guardians' hitters have struggled against right-handed pitchers this season, which could be a deciding factor given the current pitching lineup. Meanwhile, the Tigers have shown resilience against similar matchups, making them a formidable opponent. Our model suggests taking Detroit on the moneyline, leveraging their positive EV of 3.4%. Historically, our predictions have been profitable in American Totals, with a hit rate of 60.7% in the last 10 games.
For those eager to capitalize on these insights, consider starting your OddsTrader Turbo subscription to gain an edge. Additionally, stay updated with our MLB picks page for the latest betting tips and predictions.
![]() CHCC. Rea (R) 89-708% -175BetRivers | |||||||
WSHC. Cavalli (R) 65-9433% -130Caesars | |||||||
PHIA. Nola (R) 94-6555% -150BetMGM | |||||||
NYYW. Warren (R) 91-6850% -148BetRivers | |||||||
![]() TORS. Bieber (R) 91-6840% -184FanDuel | |||||||
MIAS. Alcantara (R) 77-8255% +118FanDuel | |||||||
BOSK. Harrison (L) 87-7244% -120Caesars | |||||||
![]() CLES. Cecconi (R) 86-739% -158FanDuel | |||||||
ATLJ. Wentz (L) 75-8423% -156FanDuel | |||||||
MILQ. Priester (R) 96-6324% -159BetRivers | |||||||
LAAK. Hendricks (R) 71-8885% +120SugarHouse | |||||||
![]() SDY. Darvish (R) 87-7259% -136BetRivers | |||||||
SEAG. Kirby (R) 90-6950% -125BetMGM | |||||||
![]() ATHUndecided 75-84- -106SugarHouse | |||||||
SFT. McDonald (R) 78-8114% -225BetMGM |
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