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As we gear up for the showdown between the Seattle Mariners and the Houston Astros on September 21, 2025, at Daikin Park in Houston, TX, baseball enthusiasts and bettors alike are in for a treat. The Mariners have been showing a strong form recently, and with a predicted score of 4.5 against Houston's 3.3, they appear poised to secure a victory. Our model indicates a 62.7% probability of Seattle winning with a positive EV of 5.2%. Houston, however, isn't one to be underestimated, especially at home. The Astros have a 53.4% chance to cover the spread at +1.5 with a slightly negative EV. Given these insights, Seattle looks like the stronger pick. Broadcasting on ESPN, this MLB clash promises excitement. Expect a close game with a predicted total score under 8, making it a strategic pick for bettors. Our recent predictions have been quite accurate, with a strong hit rate on Seattle's wins. For more winning picks, check out our MLB picks page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
![]() CHCC. Rea (R) 89-700% -166FanDuel | |||||||
WSHC. Cavalli (R) 65-9433% -130Caesars | |||||||
PHIA. Nola (R) 94-6554% -150BetMGM | |||||||
NYYW. Warren (R) 91-6856% -150Bet365 | |||||||
![]() TORS. Bieber (R) 91-6836% -180Bet365 | |||||||
MIAS. Alcantara (R) 77-8267% +120BetRivers | |||||||
BOSK. Harrison (L) 87-7262% -120Caesars | |||||||
![]() CLES. Cecconi (R) 86-739% -158FanDuel | |||||||
ATLJ. Wentz (L) 75-8411% -156FanDuel | |||||||
MILQ. Priester (R) 96-6333% -165Caesars | |||||||
LAAK. Hendricks (R) 71-88100% +120BetRivers | |||||||
![]() SDY. Darvish (R) 87-7244% -136FanDuel | |||||||
SEAG. Kirby (R) 90-6933% -125BetMGM | |||||||
![]() ATHUndecided 75-84- -108FanDuel | |||||||
SFT. McDonald (R) 78-8120% -225BetMGM |
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