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The upcoming MLB game between the Chicago White Sox and Arizona Diamondbacks is scheduled for April 21, 2026, at Chase Field in Phoenix, AZ. Broadcast on arid and chsn, this matchup features the Diamondbacks as home favorites with a predicted score of 5.0 to 4.2. Our picks favor the White Sox +1.5 spread with a 56.2% probability to cover, supported by strong batting performance against right-handed pitchers. Our prediction model has a positive hit rate in recent games, particularly in point spread markets.
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TBC. Legumina (R) 44-3343% -132Bet105 | |||||||
PITB. Chandler (R) 40-4073% +135Everygame | |||||||
SFL. Roupp (R) 33-4655% -122Bookmaker | |||||||
![]() DETT. Melton (R) 34-4670% -108BetAnything | |||||||
WSHC. Cavalli (R) 41-4071% +170Bookmaker | |||||||
![]() TORK. Gausman (R) 39-4121% -144Bet105 | |||||||
NYMF. Peralta (R) 34-4616% -105Bet105 | |||||||
BOSC. Early (L) 32-4672% +145Everygame | |||||||
STLM. McGreevy (R) 42-3613% -129BetOnline |