St. Louis Cardinals vs. Chicago Cubs: Key Matchup Insights

The upcoming face-off between the St. Louis Cardinals and the Chicago Cubs at Wrigley Field promises an intriguing matchup for baseball enthusiasts and bettors alike. With the Cubs coming off a strong 3-0 victory against the Cardinals in their last matchup on June 26th, they hold the home advantage. The game is scheduled for July 4th, 2025, at 2:20 PM ET, and will be broadcast on Marquee and Apple TV+. Colin Rea (R) will start for the Cubs, boasting a 4.366 ERA, while Miles Mikolas (R), with a 4.758 ERA, will pitch for the Cardinals. The Cubs are favored with 2way odds of -155. The point spread is set at -1.5 in favor of the Cubs, with a total points line at 9.5. The Cubs' home record, as seen on our MLB standings page, shows their strength at Wrigley Field, making them a formidable opponent. With an ATS record of 20-23 at home, the Cubs are looking to improve their positioning. The Cardinals, with a 26-19 ATS away record, could pose a challenge. Bettors should note the Cubs' recent performance, including their batting average of .255 and a strong pitching lineup. Injuries to key Cardinals players like Nolan Arenado (Day-to-Day) might impact their performance. The game at Wrigley Field in Chicago, IL, promises to be a thrilling encounter for fans and bettors, with strategic plays and key performances likely to influence the outcome.