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Get ready for some MLB action as the Cleveland Guardians take on the Detroit Tigers on September 17, 2025, at Comerica Park in Detroit, MI. This exciting matchup is scheduled to be broadcasted on Fox Sports 1, ensuring fans don't miss a moment of the action. The Guardians have been fairly consistent, with a solid record in their recent games. Our predictions indicate a close game, with Cleveland predicted to score 3.5 runs against Detroit's 4.0. The point spread favors Cleveland +1.5 with a 59.9% probability of covering it. Our betting tips suggest looking at the under 8.5 total runs market, which carries a 64.6% hit rate and a 12.2% EV. Historically, the Guardians have shown resilience against right-handed pitchers, which could be crucial in this game. Dive deeper into our predictions and enhance your betting strategy by visiting our MLB picks page. Ready to take your betting to the next level? Start your OddsTrader Turbo subscription today and gain an edge!
![]() CLEP. Messick (L) 13-1122% -139Bet105 | |||||||
MIAC. Paddack (R) 11-1227% -109BetAnything | |||||||
![]() DETK. Montero (R) 12-1116% -106BetAnything | |||||||
TBS. Matz (L) 12-1073% +101BetOnline | |||||||
WSHF. Griffin (L) 10-1374% +138Bet105 | |||||||
BOSC. Early (L) 9-1351% -121Bet105 | |||||||
NYMN. McLean (R) 7-1524% -152BetOnline | |||||||
![]() CHCS. Imanaga (L) 13-916% -127BetOnline | |||||||
KCK. Bubic (L) 7-1612% -116Bet105 | |||||||
![]() TEXK. Rocker (R) 11-1150% -106Bet105 | |||||||
![]() COLJ. Herget (R) 9-1479% +130Everygame | |||||||
LAAJ. Kochanowicz (R) 11-1379% -108Bookmaker | |||||||
SEAL. Castillo (R) 10-1426% -153Everygame | |||||||
![]() AZM. Kelly (R) 13-912% -142Bet105 | |||||||
SFL. Roupp (R) 9-1390% +157Everygame | |||||||
MIAJ. Junk (R) 11-12- -121BetOnline | |||||||
![]() CLET. Bibee (R) 13-11- -128MyBookie | |||||||
TBN. Martinez (R) 12-10- -125BetOnline | |||||||
KCM. Wacha (R) 7-16- -125MyBookie | |||||||
LAAJ. Soriano (R) 11-13- -143BetOnline | |||||||
SEAL. Gilbert (R) 10-14- -185BetOnline | |||||||
![]() DETC. Mize (R) 12-11- -130BetOnline | |||||||
WSHZ. Littell (R) 10-13- +134BetOnline | |||||||
BOSR. Suarez (L) 9-13- +119Heritage | |||||||
![]() COLT. Sugano (R) 9-14- - | |||||||
![]() AZE. Rodriguez (L) 13-9- -138BetOnline | |||||||
SFT. Mahle (R) 9-13- +174Heritage |