- LAST 5 GAMES
- LAST 3 VS CLEVELAND
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Apr 21, 2026 6:10 PM EDT
CLE
-140o8 (-115)
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Houston Astros vs Cleveland Guardians Betting Trends
Updated:Apr 21, 2026 2:18 AM EDT
The upcoming MLB game on April 21, 2026, features the Houston Astros visiting the Cleveland Guardians at Progressive Field in Cleveland, OH. The game will be broadcast on SCHN and CLEG. Houston's starting pitcher, RHP Ryan Weiss, has a challenging 7.269 ERA and 1.9615 WHIP, struggling notably against both lefties and righties, with a strikeout rate of 9.5 per nine innings and a SIERA of 5.933. Cleveland's LHP Parker Messick offers stronger pitching with a 0.818 ERA and 0.9091 WHIP, excelling against right-handed batters and maintaining a strikeout rate of 9.7 and a SIERA of 4.088. Houston averages 5.42 runs per game with a .260 batting average, while Cleveland posts 4.04 runs with a .227 average. The spread is +1.5 favoring Houston, with an over/under of 7.5, indicating expectations of a moderately high-scoring game. Injuries to Houston's shortstop and center fielder could impact their defensive stability. These betting trends and game insights suggest Cleveland's pitching advantage at home could be decisive.
In their last matchup on April 20, 2026, Houston defeated Cleveland 9-2 with a cover of -1.5 and an over 7.5 total, providing context for bettors analyzing this series.
R. Weiss (R)HOU - Pitcher
VIEW PROPS
0-1W-L
7.269ERA
1.9615WHIP
LAST 5 GAMES
Game
Score
ATS
O/U
P. Messick (L)CLE - Pitcher
VIEW PROPS
1-0W-L
0.818ERA
0.9091WHIP
LAST 5 GAMES
- LAST 5 GAMES
- LAST 3 VS HOUSTON
Game
Score
ATS
O/U
All
- All
- 1st 5
9-15 (26th)Against the Spread13-11 (14th)
3-8Home / Away7-4
-7.0Units+4.6
-6.8Home / Away+2.6
-29.35%ROI19.09%
-61.45%Home / Away23.61%
9-15 (26th)Win - Loss13-11 (11th)
2-9Home / Away7-4
17-7Over / Under12-12
8-3Home / Away5-6
HEAD TO HEAD
34.1At Bat32.4
5.4Runs4
8.9Hits7.3
1.3Home Runs1
5.1Runs Batted In3.8
4.1Base on Balls3.8
7.8Strikeouts7.8
0.5Stolen Base0.8
0.3Batting Average0.2
0.3Intentional Walks0
0.5Hit by Pitch0.4
0Sacrifice Hit0.1
0.4Sacrifice Fly0.1
15Total Bases12.3
3.6Extra Base Hits2.8
0.8Ground into DP0.7
5.9Earned Run Average4.1
8.7Innings Pitched8.8
8.8Hits Allowed7.5
5.9Total Runs4.3
5.8Earned Runs4
1.4Home Runs Allowed1.3
5.4Walks3.5
9.5Strikeouts9.7
1.6WHIP1.3
0Shutout0
0Intentional Walks0.1
0.3Hold0.7
0.8Ground into DP0.7
6.7Ground ball Outs7.2
4.7Fly Outs4.5
0.5Wild Pitches0.5
0Balks0
0Pickoffs0.1
160.1Pitches Thrown150.9
33.7Total Chances34
26.2Putout26.4
7.2Total Assists7.1
0.4Errors0.4
0.9Double Plays0.8
0.7Stolen Bases Allowed0.9
0.2Caught Stealing (C)0.1
0.2Stolen Base %0.1
0Passed Balls0
0.5Wild Pitches0.5
1Fielding Percentage1
SCHN, CLEG
MLB
Money
- Run Line
- Money
- Total
- Merged
Game
- Game
- 1st 5
MLBTue 04/21
 CLEP. Messick (L) 13-11100% -140BetOnline | |||||||
 MIAC. Paddack (R) 11-120% -110Bet105 | |||||||
 DETK. Montero (R) 12-11100% -110BetAnything | |||||||
 TBS. Matz (L) 12-10100% -104BetOnline | |||||||
 WSHF. Griffin (L) 10-1380% +130Everygame | |||||||
 BOSC. Early (L) 9-13100% +105Everygame | |||||||
 NYMN. McLean (R) 7-150% -173BetOnline | |||||||
 CHCS. Imanaga (L) 13-950% -113Bet105 | |||||||
 KCK. Bubic (L) 7-160% -126BetOnline | |||||||
 TEXK. Rocker (R) 11-11- -115BetOnline | |||||||
 COLUndecided 9-14- +121MyBookie | |||||||
 LAAJ. Kochanowicz (R) 11-1333% -105Bet105 | |||||||
 SEAL. Castillo (R) 10-1433% -164Bet105 | |||||||
 AZM. Kelly (R) 13-90% -145BetAnything | |||||||
 SFL. Roupp (R) 9-13100% +165BetOnline |
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