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FINAL
Apr 21, 2026 6:10 PM EDT
HOU 5 vs CLE 8
CLE
-148o8½ (-126)
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Houston Astros vs Cleveland Guardians Odds
Updated:Apr 21, 2026 2:20 AM EDT
The upcoming MLB game between the Houston Astros and Cleveland Guardians is scheduled for April 21, 2026, at Progressive Field in Cleveland, OH. The game will be broadcast on cleg. Current odds favor the Cleveland Guardians with a moneyline of -140, while the Houston Astros stand at +127. The run line opened at +1.5 -110 for Houston and -1.5 -110 for Cleveland but has shifted to +1.5 -160 and -1.5 +140 respectively, indicating a market adjustment favoring Houston's run line. Totals are set at over 8 -115 and under 8 -105. These betting lines provide insightful data for bettors analyzing the matchup. For more detailed league betting odds, visit the MLB odds page.
MONEYLINE (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
HoustonMONEYLINE
+8.8%
EV
+8.8%
ClevelandMONEYLINE
-10.3%
EV
-10.3%
Total (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
OVERTotal
-41.5%
EV
-41.5%
UNDERTotal
+28.9%
EV
+28.9%
Run Line (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
HoustonRun Line
-24.0%
EV
-24.0%
ClevelandRun Line
+22.0%
EV
+22.0%
MONEYLINE (1st 5)
BEST LINE
HoustonMONEYLINE
ClevelandMONEYLINE
Total (1st 5)
BEST LINE
OVERTotal
UNDERTotal
Run Line (1st 5)
BEST LINE
HoustonRun Line
ClevelandRun Line
MLB
Money
Game
- Game
- 1st 5
MLBThu 06/25
 TBC. Legumina (R) 44-3344% -135BetAnything | |||||||
 PITB. Chandler (R) 40-4071% +135Everygame | |||||||
 SFL. Roupp (R) 33-4659% -122JustBet | |||||||
 DETT. Melton (R) 34-4667% -104JustBet | |||||||
 WSHC. Cavalli (R) 41-4070% +163Bookmaker | |||||||
 TORK. Gausman (R) 39-4119% -144Bet105 | |||||||
 NYMF. Peralta (R) 34-4618% -102Bookmaker | |||||||
 BOSC. Early (L) 32-4670% +145Everygame | |||||||
 STLM. McGreevy (R) 42-3612% -129BetOnline |
RAYS...
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