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FINAL
Apr 21, 2026 6:10 PM EDT
HOU 5 vs CLE 8
CLE
-148o8½ (-126)
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Houston Astros vs Cleveland Guardians Picks
Updated:Apr 21, 2026 2:09 AM EDT
The Houston Astros visit the Cleveland Guardians at Progressive Field in Cleveland, OH on April 21, 2026, for an MLB regular-season game broadcast on cleg. Our picks and betting tips favor Cleveland with a predicted score of 4.21 to 4.37 and a 64.3% hit rate on Cleveland covering the -1.5 spread. The predicted total score is approximately 6, supporting an under 8 bet with a 76.4% hit rate and positive expected value. Houston's hitters perform moderately well against right-handed pitchers, while Cleveland's offense shows similar tendencies, influencing spread and total bets. Our prediction model has been profitable in recent games, winning 6 of the last 10 point spread bets with a high expected value. For more detailed MLB picks and predictions, visit MLB Picks and Predictions.
UPCOMING GAME PREDICTION
Run Line
Money
Total
HOUMoney
CONSENSUS LINE
135
PROJECTION
CLE (4.2) - HOU (4.4)
COVER PROBABILITY
EXPECTED VALUE
+8.8%
BET RATING
SEASON COVER %
9/24
38%
MLB
Money
Game
- Game
- 1st 5
MLBThu 06/25
 TBC. Legumina (R) 44-3342% -135Bet105 | |||||||
 PITB. Chandler (R) 40-4071% +135Everygame | |||||||
 SFL. Roupp (R) 33-4655% -122Bookmaker | |||||||
 DETT. Melton (R) 34-4670% -108BetAnything | |||||||
 WSHC. Cavalli (R) 41-4073% +163JustBet | |||||||
 TORK. Gausman (R) 39-4121% -144Bet105 | |||||||
 NYMF. Peralta (R) 34-4616% -105Bet105 | |||||||
 BOSC. Early (L) 32-4672% +145Everygame | |||||||
 STLM. McGreevy (R) 42-3613% -129BetOnline |
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