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FINAL
Apr 22, 2026 1:10 PM EDT
HOU 2 vs CLE 0
CLE
-163o7½ (-125)
SCHN, CLEGBETCAST
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Houston Astros vs Cleveland Guardians Odds April 22
Updated:Apr 22, 2026 2:08 AM EDT
The Houston Astros face the Cleveland Guardians on April 22, 2026, at Progressive Field in Cleveland, OH. This MLB regular season game is broadcast on the SCHN network. Current odds show the Guardians as favorites with a moneyline of -138 at BetOnline, compared to the Astros at +125. The run line opened at +1.5 -110 for Houston and -1.5 -110 for Cleveland but now stands at +1.5 -172 for the Astros and -1.5 +151 for the Guardians, indicating a shift favoring Houston on the spread. Totals are set at 8 runs, with the under favored at -115. These betting lines provide valuable insights into market expectations for this matchup. For more details, visit the MLB odds page.
MONEYLINE (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
HoustonMONEYLINE
+6.9%
EV
+6.9%
ClevelandMONEYLINE
-7.5%
EV
-7.5%
Total (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
OVERTotal
-25.4%
EV
-25.4%
UNDERTotal
+16.2%
EV
+16.2%
Run Line (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
HoustonRun Line
+2.7%
EV
+2.7%
ClevelandRun Line
-3.5%
EV
-3.5%
MONEYLINE (1st 5)
BEST LINE
HoustonMONEYLINE
ClevelandMONEYLINE
Total (1st 5)
BEST LINE
OVERTotal
UNDERTotal
Run Line (1st 5)
BEST LINE
HoustonRun Line
ClevelandRun Line
MLB
Money
Game
- Game
- 1st 5
MLBThu 06/25
 TBC. Legumina (R) 44-3344% -135BetAnything | |||||||
 PITB. Chandler (R) 40-4071% +135Everygame | |||||||
 SFL. Roupp (R) 33-4659% -122JustBet | |||||||
 DETT. Melton (R) 34-4667% -104JustBet | |||||||
 WSHC. Cavalli (R) 41-4070% +163Bookmaker | |||||||
 TORK. Gausman (R) 39-4119% -144Bet105 | |||||||
 NYMF. Peralta (R) 34-4618% -102Bookmaker | |||||||
 BOSC. Early (L) 32-4670% +145Everygame | |||||||
 STLM. McGreevy (R) 42-3612% -129BetOnline |
RAYS...
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