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The upcoming MLB game between Houston Astros and Cleveland Guardians is scheduled for April 22, 2026, at Progressive Field in Cleveland, OH, broadcasted on schn. Our picks favor Houston covering the +1.5 spread with a 61.7% probability, while the predicted final score is Cleveland 5 to Houston 4. Cleveland's hitters face a right-handed starting pitcher, showing a slight edge in performance. Our prediction model has been profitable, with a 61.7% hit rate on similar spread markets. For detailed betting tips, visit our MLB picks and predictions.
TBC. Legumina (R) 44-3344% -135Bet105 | |||||||
PITB. Chandler (R) 40-4071% +135Everygame | |||||||
SFL. Roupp (R) 33-4659% -123Bookmaker | |||||||
![]() DETT. Melton (R) 34-4667% -108BetAnything | |||||||
WSHC. Cavalli (R) 41-4070% +163Bookmaker | |||||||
![]() TORK. Gausman (R) 39-4119% -144Bet105 | |||||||
NYMF. Peralta (R) 34-4618% -102Bookmaker | |||||||
BOSC. Early (L) 32-4670% +145Everygame | |||||||
STLM. McGreevy (R) 42-3612% -129BetOnline |