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The upcoming MLB game on May 16, 2026, features the San Diego Padres visiting the Seattle Mariners at T-Mobile Park in Seattle, WA. Broadcast on Fox, this matchup showcases the Mariners as slight favorites with a Moneyline of -154, while the Padres hold +139. The run line opened at +1.5 -110 for the Padres and -1.5 -110 for the Mariners, now adjusted to +1.5 -160 and -1.5 +140 respectively, indicating a market shift favoring the Padres on the spread. Totals are set at 7 runs with the Over at -120 and Under at +100. This data-driven analysis of odds and betting lines provides a comprehensive view for bettors evaluating San Diego Padres vs Seattle Mariners. For more detailed insights, visit the MLB odds page.
CINN. Lodolo (L) 35-370% +119BetOnline | |||||||
PHIA. Painter (R) 40-33- -109BetOnline | |||||||
WSHZ. Littell (R) 39-35- -126Bet105 | |||||||
HOUP. Lambert (R) 34-41- +100BetOnline | |||||||
LADS. Ohtani (R) 47-27- -175BetOnline | |||||||
![]() AZE. Rodriguez (L) 37-36- -160Bookmaker | |||||||
BOSJ. Bennett (L) 29-41- -122BetOnline | |||||||
NYYC. Rodón (L) 44-27- -180Bet105 | |||||||
ATLJ. Ritchie (R) 46-25- -135BetOnline | |||||||
MILB. Sproat (R) 44-260% -115Everygame | |||||||
![]() CHCJ. Assad (R) 38-36- -180BetOnline | |||||||
SEAG. Kirby (R) 38-36- -139Bet105 | |||||||
![]() ATHA. Civale (R) 36-37- +104BetOnline |