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The upcoming MLB game between the San Diego Padres and Seattle Mariners is scheduled for May 16, 2026, at 7:15 PM EDT, taking place at T-Mobile Park in Seattle, WA. This matchup will be broadcast on Fox. Our picks and betting tips indicate a predicted score of Seattle 4.67 and San Diego 3.32, favoring the Mariners on the moneyline with a 64.3% coverage and an EV of 3.7%. The Padres show a 51.9% probability of covering the +1.5 spread, while the Mariners have a 48.1% chance to cover the -1.5 spread, suggesting a closely contested game. Considering the starting pitchers' handedness and hitters' performance against them, bettors may find value in point spread bets. Our model has been profitable in recent MLB games, winning 6 out of the last 10 point spread bets, with a hit rate exceeding 50% and positive expected value. For more detailed analysis, visit the MLB picks and predictions.
CINN. Lodolo (L) 35-370% +119BetOnline | |||||||
PHIA. Painter (R) 40-33- -109BetOnline | |||||||
WSHZ. Littell (R) 39-35- -126Bet105 | |||||||
HOUP. Lambert (R) 34-41- +100BetOnline | |||||||
LADS. Ohtani (R) 47-27- -175BetOnline | |||||||
![]() AZE. Rodriguez (L) 37-36- -160Bookmaker | |||||||
BOSJ. Bennett (L) 29-41- -122BetOnline | |||||||
NYYC. Rodón (L) 44-27- -180Bet105 | |||||||
ATLJ. Ritchie (R) 46-25- -135BetOnline | |||||||
MILB. Sproat (R) 44-260% -115Everygame | |||||||
![]() CHCJ. Assad (R) 38-36- -180BetOnline | |||||||
SEAG. Kirby (R) 38-36- -139Bet105 | |||||||
![]() ATHA. Civale (R) 36-37- +104BetOnline |