Penn State Nittany Lions vs Iowa Hawkeyes Picks

Before the much-anticipated game on October 18, 2025, between the Penn State Nittany Lions and the Iowa Hawkeyes, excitement is building among college football enthusiasts. Set at the renowned Kinnick Stadium in Iowa City, IA, this NCAAF clash promises to be a spectacle. Fans can catch the live action on Peacock, as the Nittany Lions, with a predicted score of 25, take on the Hawkeyes, predicted to score 20. With Penn State holding a 66.3% chance of winning, this matchup is drawing significant attention from bettors. Our prediction model has been particularly profitable with Penn State's games, showcasing a solid hit rate in recent matches. Our best bet suggests taking Penn State +1.5, given the expected value and coverage percentage. For enthusiasts looking to make informed betting decisions, our insights and analytics provide a competitive edge. Discover more detailed analysis and check out our NCAAF picks. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

Our prediction has consistently outperformed in the American Total market, making it a high EV option for this game. With a coverage percentage of 61.0% for Penn State +1.5, bettors have a good chance to capitalize on this opportunity. As Saturday football approaches, ensure you have the latest insights and picks to maximize your betting strategy.