Oct 4, 2025 3:30 PM EDT

Week 6

#24 Virginia

4-0

Louisville

LOU

-6½ (-110)o61½ (-110)

ESPN2, 209, ESPN Networks

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Virginia Cavaliers Vs Louisville Cardinals Odds

Updated:Oct 3, 2025 4:14 AM EDT

Get ready for an electrifying college football showdown as the Virginia Cavaliers take on the Louisville Cardinals on October 4, 2025. This Saturday football clash will unfold at the L&N Federal Credit Union Stadium in Louisville, KY, a venue known for its vibrant atmosphere. As part of the NCAAF league, this matchup promises intense action, and bettors are keeping a close eye on the odds.

Currently, the Louisville Cardinals are favored with a point spread of -6½ -110, while the Virginia Cavaliers stand as the underdogs with a spread of +6½ -110. The opening odds showed a similar trend, highlighting the Cardinals' strong home advantage. With both teams showcasing impressive form, the betting lines are drawing significant attention.

Broadcasted on ESPN2, this game is a must-watch for fans and bettors alike. The best odds available for the Cardinals to win outright are -250 at Caesars, while the Cavaliers offer a compelling +205. For those interested in totals, the over is set at 61½ -110, indicating expectations of a high-scoring affair.

Analyzing these odds and betting insights, it's clear that the Cardinals have the upper hand, but the Cavaliers are no strangers to surprises. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook. For more in-depth analysis, visit our NCAAF odds page.

What are the odds for the Virginia Cavaliers vs Louisville Cardinals game?

NCAAF

ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

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This Week

Last Week

NCAAF Fri 10/03

Personalize your notifications and get updates on the teams, players or events you care about most. FRI 10/037:00 PM Charlotte 1-3 87% +28½ -110Bet365
South Florida 3-1 13% -28 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FRI 10/037:00 PM Western Kentucky 4-1 51% +3 -118BetRivers
Delaware 3-1 49% -2½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. FRI 10/0310:00 PM New Mexico 3-1 47% +3 -121BetRivers
San Jose State 1-3 53% -2½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FRI 10/0310:30 PM West Virginia 2-3 61% +19 -110Caesars
#23Brigham Young 4-0 39% -18½ -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. FRI 10/0310:30 PM Colorado State 1-3 72% +6½ -110Bet365
San Diego State 3-1 28% -5½ -122FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/0412:00 PM Air Force 1-3 82% +12½ -108FanDuel
Navy 4-0 18% -12 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/0412:00 PM Kentucky 2-2 72% +20½ -105BetMGM
#12Georgia 3-1 28% -20½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/0412:00 PM #14Iowa State 5-0 32% +2 -114BetRivers
Cincinnati 3-1 68% -1½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/0412:00 PM Wisconsin 2-2 63% +17½ -114FanDuel
#20Michigan 3-1 37% -17 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/0412:00 PM Clemson 1-3 33% -14 -110Bet365
North Carolina 2-2 67% +14½ -105FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/0412:00 PM Boston College 1-3 62% +6½ -110Bet365
Pittsburgh 2-2 38% -6 -114SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/0412:00 PM Ohio 3-2 23% -14½ -110Bet365
Ball State 1-3 77% +14½ -108Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/0412:00 PM #22Illinois 4-1 26% -9½ -110Bet365
Purdue 2-2 74% +9½ -104FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/0412:00 PM Kansas State 2-3 59% +6½ -105BetMGM
Baylor 3-2 41% -5½ -118BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/0412:00 PM Army 1-3 63% -6½ -113Caesars
UAB 2-2 37% +7½ -128FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/041:00 PM UTSA 2-2 45% -6½ -106FanDuel
Temple 2-2 55% +6½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/041:00 PM Wake Forest 2-2 57% +6½ -114BetRivers
Virginia Tech 2-3 43% -5½ -118BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/042:00 PM Campbell 1-4 - +42½ -110Bet365
North Carolina State 3-2 - -42½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/042:30 PM Western Michigan 2-3 15% -13½ -110Caesars
Massachusetts 0-4 85% +14 -114BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/043:00 PM Oklahoma State 1-3 73% +20½ -110Bet365
Arizona 3-1 27% -20½ -105FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/043:30 PM Oregon State 0-5 72% +2 -110BetRivers
Appalachian State 2-2 28% -1½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/043:30 PM #24Virginia 4-1 38% +6½ -105BetMGM
Louisville 4-0 62% -6 -115BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/043:30 PM Washington 3-1 58% -6 -112BetRivers
Maryland 4-0 42% +6½ -105FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/043:30 PM Central Michigan 3-2 35% -7½ -110Caesars
Akron 1-4 65% +7½ -105BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/043:30 PM Eastern Michigan 1-4 75% +10½ -114BetRivers
Buffalo 2-3 25% -9½ -118BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/043:30 PM James Madison 3-1 22% -20 -110Caesars
Georgia State 1-3 78% +20½ -115BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/043:30 PM Louisiana-Monroe 3-1 45% +11½ -105Caesars
Northwestern 2-2 55% -11½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/043:30 PM Miami (OH) 1-3 28% -4½ -110Caesars
Northern Illinois 1-3 72% +5½ -114SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/043:30 PM #7Penn State 3-1 27% -24½ -105Caesars
UCLA 0-4 73% +25 -114BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/043:30 PM #9Texas 3-1 32% -5½ -105Caesars
Florida 1-3 68% +5½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/043:30 PM #16Vanderbilt 5-0 58% +10½ -110Caesars
#10Alabama 3-1 42% -10½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/043:30 PM Syracuse 3-2 48% +18 -113BetRivers
SMU 2-2 52% -17½ -105BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/043:30 PM Florida International 2-2 64% +7½ -115BetMGM
Connecticut 3-2 36% -7 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/043:30 PM Boise State 3-1 73% +21 -114BetRivers
#21Notre Dame 2-2 27% -20½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/044:00 PM Michigan State 3-1 41% +11½ -110Caesars
Nebraska 3-1 59% -11 -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/044:00 PM Kent State 1-3 72% +45½ -107Caesars
#5Oklahoma 4-0 28% -45½ -109BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/044:00 PM Texas State 3-1 0% -13½ -110Caesars
Arkansas State 1-4 100% +14 -115BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/046:00 PM Coastal Carolina 2-2 71% +20½ -110Bet365
Old Dominion 3-1 29% -20 -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/047:00 PM South Alabama 1-4 77% +1½ -115BetMGM
Troy 2-2 23% +1½ -115FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/047:00 PM Florida Atlantic 1-3 63% +4½ -105FanDuel
Rice 3-2 37% -4½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/047:00 PM #11Texas Tech 4-0 20% -11 -110Caesars
Houston 4-0 80% +12 -114SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/047:00 PM UNLV 4-0 24% -3½ -109BetRivers
Wyoming 2-2 76% +4½ -130BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/047:30 PM Kansas 3-2 29% -4½ -105BetMGM
UCF 3-1 71% +5 -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/047:30 PM Minnesota 3-1 94% +23½ -105BetMGM
#1Ohio State 4-0 6% -23½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/047:30 PM #3Miami (FL) 4-0 47% -4 -110Caesars
#18Florida State 3-1 53% +4½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/047:30 PM Colorado 2-3 70% +13½ -104FanDuel
TCU 3-1 30% -13½ -105Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/047:30 PM Mississippi State 4-1 45% +16 -115BetRivers
#6Texas A&M 4-0 55% -14½ -115FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/048:00 PM Tulsa 2-3 89% +20½ -110Bet365
Memphis 5-0 11% -20 -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/0410:30 PM Duke 3-2 18% -2½ -115BetMGM
California 4-1 82% +3 -112BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 10/0410:30 PM Nevada 1-3 60% +14 -118BetRivers
Fresno State 4-1 40% -13½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTHU 10/029:00 PM Sam Houston State 0-5 10 -1½ -110Bet365
New Mexico State 3-2 37 +2½ -115SugarHouse

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