Nov 22, 2025 7:00 PM EST

Week 13

Nebraska

4-6

Penn State

PSU

-7½ (-114)o44½ (-118)

NBC

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Nebraska Cornhuskers vs Penn State Nittany Lions Picks

Updated:Nov 22, 2025 2:17 AM EST

The upcoming Saturday football matchup on November 22, 2025, features the Nebraska Cornhuskers vs Penn State Nittany Lions at West Shore Home Field at Beaver Stadium in University Park, PA. This NCAAF regular season Week 13 game is set to be broadcast on NBC, delivering an exciting opportunity for football fans and sports bettors alike.

Our picks for this game lean towards a competitive contest with Penn State predicted to edge out Nebraska with a score of 26-21. The point spread favors Nebraska at +8, reflecting a 54.5% hit rate and a positive EV of 1.0%, suggesting value for bettors considering the Cornhuskers. Meanwhile, the total points are expected to go over 44.5 with a 55.4% hit rate and an EV of 3.2%, forecasting an engaging, high-scoring game.

Our prediction model has been profitable in recent games, especially in the American Total market, which has shown a strong cover percentage and positive expected value. These insights can help bettors make smarter decisions and identify profitable betting opportunities. For a deeper dive into the NCAAF action, check out our comprehensive NCAAF picks and predictions.

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What are the best betting picks for Nebraska Cornhuskers vs Penn State Nittany Lions?

NCAAF

ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

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NCAAF Sat 11/22

Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Rutgers 5-5 69% +31½ -112FanDuel
#1Ohio State 10-0 31% -31 -115BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Tulsa 3-7 77% +10 -105BetMGM
Army 5-4 23% -9½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Delaware 5-5 67% +18 -120BetRivers
Wake Forest 7-3 33% -17½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM #13Miami (FL) 8-2 75% -17½ -115FanDuel
Virginia Tech 3-7 25% +18 -109Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM #22Missouri 7-3 65% +5½ -105BetMGM
#8Oklahoma 8-2 35% -5½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Louisville 7-3 46% +4 -110Caesars
SMU 7-3 54% -3½ -117SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Kansas 5-5 66% +3½ -113Caesars
Iowa State 6-4 34% -3½ -105BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Minnesota 6-4 60% +3½ -105Bet365
Northwestern 5-5 40% -3½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Samford 1-10 - +55½ -110FanDuel
#3Texas A&M 10-0 - -54½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:45 PM Charlotte 1-9 37% +44 -110Bet365
#4Georgia 9-1 63% -43½ -112Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/221:00 PM Old Dominion 7-3 44% -10½ -110Bet365
Georgia Southern 5-5 56% +11 -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/221:00 PM Washington State 5-5 51% +14 -110BetMGM
James Madison 9-1 49% -13½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/221:00 PM Baylor 5-5 69% +7 -115Bet365
Arizona 7-3 31% -6½ -114Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Ball State 4-6 31% +28½ -117Caesars
Toledo 6-4 69% -27½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Nevada 2-8 74% +7½ -120FanDuel
Wyoming 4-6 26% -6½ -112Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Missouri State 7-3 79% +6½ -109BetRivers
Kennesaw State 7-3 21% -6½ -105FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Mercer 9-1 - +27½ -110Bet365
Auburn 4-6 - -27½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Eastern Illinois 3-8 - +50½ -110FanDuel
#10Alabama 8-2 - -50½ -107Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:30 PM Marshall 5-5 27% -4½ -115FanDuel
Appalachian State 4-6 73% +5½ -115Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM Connecticut 8-3 16% -6½ -110Bet365
Florida Atlantic 4-6 84% +7½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM New Mexico State 3-7 76% +3½ -117BetRivers
UTEP 2-8 24% -3 -113Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM Sam Houston State 2-8 50% +6½ -104Caesars
Middle Tennessee 1-9 50% -6½ -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM Liberty 4-6 76% +2½ -130BetMGM
Louisiana Tech 5-5 24% +1½ -115FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM South Florida 7-3 27% -21½ -108FanDuel
UAB 3-7 73% +21½ -109Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Duke 5-5 29% -6½ -114Caesars
North Carolina 4-6 71% +7 -115BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Arkansas 2-8 87% +9 -110Bet365
#17Texas 7-3 13% -8 -115BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM #15USC 8-2 40% +10½ -112BetRivers
#7Oregon 9-1 60% -10 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Michigan State 3-7 41% +17½ -120FanDuel
Iowa 6-4 59% -16½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM East Carolina 7-3 33% -2½ -110Bet365
UTSA 5-5 67% +2½ -108Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Kentucky 5-5 83% +9½ -110Bet365
#14Vanderbilt 8-2 17% -8 -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Southern Miss 7-3 43% +1½ -115FanDuel
South Alabama 3-7 57% +1½ -115BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Jacksonville State 7-3 40% +1½ -112FanDuel
Florida International 5-5 60% -1 -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Syracuse 3-7 28% +36½ -105BetMGM
#9Notre Dame 8-2 72% -35 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:45 PM #24Tulane 8-2 16% -9 -110Bet365
Temple 5-5 84% +9½ -105FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM Oklahoma State 1-9 77% +13½ -115Caesars
UCF 4-6 23% -13 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM #18Michigan 8-2 28% -13½ -120FanDuel
Maryland 4-6 72% +14 -107Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM TCU 6-4 72% +1½ -110Caesars
#23Houston 8-2 28% -1 -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM Kansas State 5-5 31% +17½ -112BetRivers
#12Utah 8-2 69% -15½ -125BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM Georgia State 1-9 77% +10½ -110Bet365
Troy 6-4 23% -9½ -118FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:15 PM Coastal Carolina 6-4 41% +24 -108Caesars
South Carolina 3-7 59% -23½ -122FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:30 PM Furman 6-5 - +42 -110BetRivers
Clemson 5-5 - -41½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/225:00 PM Louisiana-Monroe 3-7 71% +20½ -110FanDuel
Texas State 4-6 29% -19½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM Pittsburgh 7-3 83% +2½ -105BetMGM
#16Georgia Tech 9-1 17% -2½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM Nebraska 7-3 66% +8 -115Bet365
Penn State 4-6 34% -7½ -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM Colorado State 2-8 100% +17½ -115BetMGM
Boise State 6-4 0% -16½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM New Mexico 7-3 11% -3½ -102FanDuel
Air Force 3-7 89% +4 -120SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM #20Tennessee 7-3 12% -3½ -118FanDuel
Florida 3-7 88% +4½ -112BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM California 6-4 19% -2½ -120FanDuel
Stanford 3-7 81% +3½ -113Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM #21Illinois 7-3 43% -8 -114BetRivers
Wisconsin 3-7 57% +8½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM North Texas 9-1 12% -17½ -115BetMGM
Rice 5-5 88% +18½ -115FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:45 PM Western Kentucky 8-2 92% +22½ -114FanDuel
LSU 6-4 8% -21½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/228:00 PM #11Brigham Young 9-1 62% -2½ -114FanDuel
Cincinnati 7-3 38% +3 -113Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/228:00 PM #25Arizona State 7-3 15% -7 -110Caesars
Colorado 3-7 85% +7½ -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2210:30 PM Washington 7-3 13% -10½ -105FanDuel
UCLA 3-7 87% +10½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2210:30 PM San Jose State 3-7 89% +12½ -110Bet365
San Diego State 8-2 11% -11½ -114FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2210:30 PM Utah State 5-5 83% +2½ -104Caesars
Fresno State 7-3 17% -2½ -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTUE 11/187:00 PM Massachusetts 0-11 14 +34½ -115BetMGM
Ohio 7-4 42 -33½ -115BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTUE 11/187:00 PM Akron 5-7 19 +3 -114BetRivers
Bowling Green 3-8 16 -2½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTUE 11/187:00 PM Western Michigan 7-4 35 -6 -115Bet365
Northern Illinois 3-8 19 +7½ -122FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALWED 11/197:00 PM Miami (OH) 6-5 37 -1½ -120BetMGM
Buffalo 5-6 20 +2½ -107Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALWED 11/197:00 PM Central Michigan 7-4 28 -7½ -110Bet365
Kent State 4-7 16 +8½ -115FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTHU 11/207:30 PM Louisiana 5-6 34 +3 -120BetRivers
Arkansas State 5-6 30 -2½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. FINALFRI 11/218:00 PM Florida State 5-6 11 -6½ -114FanDuel
North Carolina State 6-5 21 +7 -118SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. FINALFRI 11/2110:30 PM Hawaii 7-4 10 +2½ -105BetMGM
UNLV 9-2 38 -2 -121SugarHouse

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