Oct 18, 2025 7:30 PM EDT

Week 8

USC

4-2

#16 Notre Dame

NBC

MATCHUP PREDICTION ODDS BOOSTS PLAYER PROPS GAME PROPS INJURIES WEATHER

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USC Trojans Vs Notre Dame Fighting Irish Injury Report

Updated:Oct 12, 2025 4:28 AM EDT

As the USC Trojans prepare to face the Notre Dame Fighting Irish on October 18, 2025, at Notre Dame Stadium in South Bend, Indiana, the injury report plays a crucial role in shaping the game's outcome. Both teams are grappling with significant injuries that could impact their performance. For the Fighting Irish, tight end Cooper Flanagan is questionable after undergoing left Achilles surgery, while wide receiver Jaden Greathouse is out due to a right thigh injury. On the Trojans' side, offensive lineman Kilian O'Connor will miss the game with a knee injury, and kicker Caden Chittenden is out with an undisclosed ailment.

These injuries could affect betting strategies, as key players' absences may alter team dynamics. Bettors should consider these factors when placing wagers and explore options at U.S. regulated sportsbooks. This Saturday football clash, broadcasted on NBC, promises to be a thrilling encounter, with both teams eager to capitalize on their strengths. Stay informed with our detailed NCAAF injury report to make smarter betting choices. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

How will player injuries affect the USC vs Notre Dame game?

NCAAF

ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

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This Week

Last Week

NCAAF Wed 10/08

Personalize your notifications and get updates on the teams, players or events you care about most. FINALWED 10/087:30 PM Missouri State 3-3 22 -2½ -115Bet365
Middle Tennessee 1-5 20 +3 -112BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. FINALWED 10/088:00 PM Liberty 2-4 19 -2 -110Caesars
UTEP 1-5 8 +2½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTHU 10/097:00 PM Louisiana Tech 4-2 7 -4½ -110Caesars
Kennesaw State 4-2 35 +6 -120SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTHU 10/097:30 PM East Carolina 3-3 19 +7 -105Caesars
Tulane 5-1 26 -6½ -118FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTHU 10/098:00 PM Southern Miss 4-2 38 -3 +100Caesars
Georgia Southern 2-4 35 +3½ -121SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTHU 10/098:00 PM Jacksonville State 3-3 29 -7 -105Bet365
Sam Houston State 0-6 27 +7½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALFRI 10/107:30 PM #24South Florida 5-1 63 +2½ -105Bet365
North Texas 5-1 36 -2½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALFRI 10/109:00 PM Fresno State 5-2 21 -5½ -105Caesars
Colorado State 2-4 49 +6 -117SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. FINALFRI 10/109:00 PM Rutgers 3-3 19 +10 -114BetRivers
Washington 5-1 38 -9½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/1112:00 PM UCF 3-3 11 +10½ -110FanDuel
Cincinnati 5-1 20 -10 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/1112:00 PM Charlotte 1-5 7 +17½ -110Caesars
Army 3-3 24 -17 -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/1112:00 PM Louisiana 2-4 14 +18½ -109SugarHouse
James Madison 5-1 24 -18½ -105FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/1112:00 PM Pittsburgh 4-2 34 +11 -110BetRivers
#25Florida State 3-3 31 -10½ -105BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/1112:00 PM UCLA 2-4 38 +7½ -120BetMGM
Michigan State 3-3 13 -7 -115Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/1112:00 PM Miami (OH) 3-3 20 -11½ -105FanDuel
Akron 2-5 7 +12½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/1112:00 PM Toledo 3-3 23 -10½ -110Caesars
Bowling Green 3-3 28 +11½ -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/1112:00 PM #8Alabama 5-1 27 -3 -115Caesars
#14Missouri 5-1 24 +3½ -110BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/1112:00 PM #1Ohio State 6-0 34 -14½ -110Bet365
#17Illinois 5-2 16 +14½ -105Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/1112:00 PM Stanford 2-4 10 +19½ -105Bet365
SMU 4-2 34 -19½ -105FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/1112:00 PM Houston 5-1 39 -14½ -108FanDuel
Oklahoma State 1-5 17 +15½ -114SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/1112:45 PM Washington State 3-3 21 +33½ -110FanDuel
#4Ole Miss 6-0 24 -33 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/111:00 PM Northern Illinois 1-5 10 -1 -110Bet365
Eastern Michigan 2-5 16 +1½ -114Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/112:30 PM Massachusetts 0-6 6 +1½ -110FanDuel
Kent State 2-4 42 -1 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/113:30 PM Old Dominion 4-2 24 -14½ -110Caesars
Marshall 3-3 48 +14½ -105FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/113:30 PM Appalachian State 4-2 41 -2½ -115BetMGM
Georgia State 1-5 20 +3 -114BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/113:30 PM Northwestern 4-2 22 +21 -110BetRivers
Penn State 3-3 21 -20½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/113:30 PM Virginia Tech 2-5 20 +14 -108BetRivers
#13Georgia Tech 6-0 35 -13½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/113:30 PM Ball State 2-4 0 +9½ -110Bet365
Western Michigan 4-3 42 -9 -115BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/113:30 PM #22Iowa State 5-2 17 -2½ -124FanDuel
Colorado 3-4 24 +3 -109BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/113:30 PM Nebraska 5-1 34 -6½ -122FanDuel
Maryland 4-2 31 +7 -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/113:30 PM TCU 4-2 28 -2½ -122FanDuel
Kansas State 3-4 41 +3 -115BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/113:30 PM North Carolina State 4-3 7 +24 -110Caesars
#16Notre Dame 4-2 36 -23½ -117SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/113:30 PM #7Indiana 6-0 30 +7 -110Caesars
#3Oregon 5-1 20 -6½ -124FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/113:30 PM Wake Forest 4-2 39 -1½ -110Bet365
Oregon State 0-7 14 +2½ -118SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/113:30 PM #6Oklahoma 5-1 6 +3 -113BetRivers
Texas 4-2 23 -2½ -115BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/113:30 PM Air Force 1-5 48 +7 -110Caesars
UNLV 6-0 51 -6½ -122FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/114:00 PM Navy 6-0 32 -9½ -110FanDuel
Temple 3-3 31 +10½ -118BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/114:15 PM Arkansas 2-4 31 +10½ -110SugarHouse
#12Tennessee 5-1 34 -10 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/116:00 PM UAB 2-4 33 +5 -110Bet365
Florida Atlantic 3-3 53 -4½ -110BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/117:00 PM Iowa 4-2 37 -5½ -105FanDuel
Wisconsin 2-4 0 +5½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/117:00 PM Louisiana-Monroe 3-3 8 -2½ -115BetMGM
Coastal Carolina 3-3 23 +3 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/117:00 PM Florida 2-4 17 +7 -110Caesars
#5Texas A&M 6-0 34 -6½ -122FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/117:00 PM San Jose State 2-4 28 -1½ -110Bet365
Wyoming 3-3 35 +1½ -107Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/117:30 PM Clemson 3-3 41 -13½ -122FanDuel
Boston College 1-5 10 +14 -108BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/117:30 PM Kansas 4-3 17 +14 -105BetMGM
#9Texas Tech 6-0 42 -13½ -118FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/117:30 PM #15Michigan 4-2 13 +3½ -118FanDuel
USC 5-1 31 -2½ -121SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/117:30 PM Rice 3-4 13 +10 -115BetRivers
UTSA 3-3 61 -9 -105Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/117:30 PM Purdue 2-4 20 +7½ -112FanDuel
Minnesota 4-2 27 -7 -115Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/117:30 PM #10Georgia 5-1 20 -4½ -110FanDuel
Auburn 3-3 10 +5½ -110BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/117:45 PM South Carolina 3-3 10 +8½ -110Caesars
#11LSU 5-1 20 -7½ -112BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. FINAL OTSAT 10/118:00 PM #18Brigham Young 6-0 33 -2½ -115Bet365
Arizona 4-2 27 +3 -121SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. FINAL OTSAT 10/118:00 PM Troy 4-2 48 +7½ -110BetMGM
Texas State 3-3 41 -7 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/119:45 PM New Mexico 3-3 25 +15 -110Caesars
Boise State 4-2 41 -14 -115BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/1110:15 PM #21Arizona State 4-2 10 +9½ -110Caesars
Utah 5-1 42 -8½ -113SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSAT 10/1110:30 PM San Diego State 5-1 44 -6 -117BetRivers
Nevada 1-5 10 +6½ -105Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. FINALSUN 10/1212:00 AM Utah State 3-3 26 -1 -114SugarHouse
Hawaii 5-2 44 +2 -110BetRivers

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USC Trojans Vs Notre Dame Fighting Irish Injury Report

Injuries

USC

Notre Dame