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Get ready for a thrilling college football showdown as the USC Trojans take on the Notre Dame Fighting Irish on October 18, 2025, at Notre Dame Stadium in South Bend, IN, broadcasted live on NBC. Both teams are known for their fierce competitiveness, and this game is no exception. The Trojans, led by a dynamic offense, have been a force to reckon with this season. Their passing game is particularly strong, averaging 325.8 yards per game, which could pose a challenge to Notre Dame's defense.
The Fighting Irish, however, have a solid record at home and are determined to maintain their dominance. With a home ATS record of 3-1, Notre Dame is not just playing for victory but also for pride. Their defense, known for its agility, will need to step up to counter USC's offensive prowess. The betting trends suggest a close game, with Notre Dame slightly favored by 8 points.
Quarterback play will be crucial, and both teams have talented players who can make a difference. Keep an eye on the odds spread and total points, which are set at 61.5, making the over/under an interesting bet. Understanding these betting insights can help you make an informed decision. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. Don't miss out on this exciting Saturday football matchup!
![]() Liberty 2-417% -10½ -105BetMGM | |||||||
![]() South Alabama 1-537% -6½ -122FanDuel | |||||||
![]() Western Kentucky 5-133% -7½ -110Caesars | |||||||
![]() Jacksonville State 3-375% +2½ -112FanDuel | |||||||
![]() Sam Houston State 0-667% +3 -117BetRivers | |||||||
East Carolina 3-333% -16½ -110Caesars | |||||||
![]() #2Miami (FL) 5-019% -12½ -115FanDuel | |||||||
Minnesota 4-289% +6½ -110Caesars | |||||||
![]() Utah State 3-343% -4 -110Caesars | |||||||
![]() California 4-20% -10½ -110Caesars | |||||||
Miami (OH) 3-30% -12½ -110FanDuel | |||||||
![]() Boston College 1-540% -1½ -110Caesars | |||||||
![]() Duke 4-264% -2½ -115BetMGM | |||||||
Bowling Green 3-30% -5½ -110FanDuel | |||||||
![]() #17Vanderbilt 5-167% -2½ -110Caesars | |||||||
![]() Michigan 4-253% -5½ -106FanDuel | |||||||
![]() Houston 5-125% -1½ -108FanDuel | |||||||
TCU 4-220% -2½ -120FanDuel | |||||||
![]() Tulane 5-133% -10½ -110Caesars | |||||||
![]() South Carolina 3-3100% +5½ -110Caesars | |||||||
UCF 3-350% -7 -110Caesars | |||||||
![]() Toledo 3-3- -24½ -110BetRivers | |||||||
![]() Massachusetts 0-6100% +17½ -115Caesars | |||||||
![]() Louisiana-Monroe 3-3- +6½ -110BetRivers | |||||||
![]() Northwestern 4-20% -3½ -110Caesars | |||||||
Appalachian State 4-2- -11½ -110Caesars | |||||||
![]() Ohio 3-3- -11½ -115BetMGM | |||||||
![]() James Madison 5-10% -2 -110Caesars | |||||||
![]() Charlotte 1-5- +12½ -110FanDuel | |||||||
![]() Clemson 3-322% -9½ -110Caesars | |||||||
![]() #3Indiana 6-010% -26½ -113BetRivers | |||||||
Marshall 3-360% +3½ -113BetRivers | |||||||
Ball State 2-4- -1½ -105FanDuel | |||||||
![]() Boise State 4-267% -10½ -110Caesars | |||||||
![]() North Texas 5-150% -5½ -110Caesars | |||||||
![]() #9Georgia 5-130% -6½ -105BetMGM | |||||||
![]() Arkansas 2-474% +7½ -110Caesars | |||||||
![]() Wisconsin 2-485% +27½ -110Caesars | |||||||
Air Force 1-50% -4½ -115FanDuel | |||||||
UAB 2-4100% +21½ -110BetMGM | |||||||
![]() Arizona State 4-294% +10½ -110Caesars | |||||||
Florida 2-4100% -9½ -112BetRivers | |||||||
![]() Louisiana 2-4- +4 -110Caesars | |||||||
![]() #18Virginia 5-10% -17½ -104FanDuel | |||||||
Rutgers 3-3100% +15½ -110SugarHouse | |||||||
![]() Georgia Southern 2-40% -6½ -113BetRivers | |||||||
![]() Colorado State 2-4100% +1 -117BetRivers | |||||||
UCLA 2-450% -2½ -118FanDuel | |||||||
Iowa 4-233% -2½ -118FanDuel | |||||||
Kentucky 2-350% +12½ -115BetMGM | |||||||
![]() #19South Florida 5-1- -21½ -110BetMGM | |||||||
Syracuse 3-3- +11½ -110Caesars | |||||||
#13Notre Dame 4-244% -7½ -110FanDuel | |||||||
#6Alabama 5-120% -8 -110Caesars | |||||||
Auburn 3-375% -1½ -110BetRivers | |||||||
Oklahoma State 1-5100% +21½ -112BetRivers | |||||||
#15Brigham Young 6-00% +3½ -120FanDuel | |||||||
![]() New Mexico 3-30% -10 -110BetRivers | |||||||
![]() Oregon State 0-7- - | |||||||
Stanford 2-4- +17½ -110Caesars |
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