Oklahoma Sooners vs South Carolina Gamecocks Picks

The upcoming clash on October 18, 2025, between the Oklahoma Sooners and the South Carolina Gamecocks at Williams-Brice Stadium in Columbia, SC, promises to be a thrilling encounter in the NCAAF league. The Gamecocks, having secured a significant victory against the Sooners in their last meeting, are riding high on confidence. The Sooners, on the other hand, are eager to avenge their previous loss and are expected to bring their A-game. Our prediction model gives the Sooners a 62% chance of winning, making them the favorites for this matchup. However, considering the Gamecocks' recent form, betting on a close game with high scoring could be wise. The game will be broadcast on SEC Network and ESPN Networks, ensuring fans won't miss any action. Our best bet for this game is the Oklahoma moneyline, given their high EV and past performance. Historically, our predictions for similar matchups have been profitable, with a hit rate of over 60%. To make the most of this exciting clash, check out our detailed NCAAF picks page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.