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The Pittsburgh Panthers are set to face off against the Syracuse Orange on October 18, 2025, at the JMA Wireless Dome in Syracuse, NY. This ACC showdown is expected to be a thrilling encounter, with both teams looking to gain an edge in their conference standings. The Panthers come into this game with a strong 4-2 record, showing resilience in both their offensive and defensive plays. Their recent victory against the Florida State Seminoles, where they scored 34 points, highlights their offensive prowess.
Syracuse, on the other hand, has had a mixed season with a 3-3 record. However, their impressive win over the Clemson Tigers earlier in the season showcased their potential to upset stronger opponents. The Orange will rely heavily on their home advantage and the support of their fans to overcome the Panthers.
The betting trends indicate that Pittsburgh is favored with a point spread of -11.5, and the total points are set at 56.5. Given Pittsburgh's recent form and their strong ATS record, they are expected to cover the spread. The game will be broadcasted on the ACC Network, providing fans with all the live action. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
![]() Liberty 2-417% -10½ -105BetMGM | |||||||
![]() South Alabama 1-537% -6½ -122FanDuel | |||||||
![]() Western Kentucky 5-133% -7½ -110Caesars | |||||||
![]() Jacksonville State 3-375% +2½ -112FanDuel | |||||||
![]() Sam Houston State 0-667% +2½ +100Caesars | |||||||
East Carolina 3-333% -16½ -110Caesars | |||||||
![]() #2Miami (FL) 5-018% -12½ -115FanDuel | |||||||
Minnesota 4-289% +6½ -110Caesars | |||||||
![]() Utah State 3-343% -4 -110Caesars | |||||||
![]() California 4-20% -10½ -110Caesars | |||||||
Miami (OH) 3-30% -12½ -110FanDuel | |||||||
![]() Boston College 1-540% -1½ -110Caesars | |||||||
![]() Duke 4-250% -2½ -115BetMGM | |||||||
Bowling Green 3-30% -5½ -110FanDuel | |||||||
![]() #17Vanderbilt 5-167% -2½ -110Caesars | |||||||
![]() Michigan 4-246% -5½ -106FanDuel | |||||||
![]() Houston 5-125% -1½ -108FanDuel | |||||||
TCU 4-220% -2½ -120FanDuel | |||||||
![]() Tulane 5-133% -10½ -110Caesars | |||||||
![]() South Carolina 3-3100% +5½ -110Caesars | |||||||
UCF 3-350% -7 -110Caesars | |||||||
![]() Toledo 3-3- -24½ -110BetRivers | |||||||
![]() Massachusetts 0-6100% +17½ -115Caesars | |||||||
![]() Louisiana-Monroe 3-3- +6½ -110BetRivers | |||||||
![]() Northwestern 4-20% -3½ -110Caesars | |||||||
Appalachian State 4-2- -11½ -110Caesars | |||||||
![]() Ohio 3-3- -11½ -115BetMGM | |||||||
![]() James Madison 5-10% -2 -110Caesars | |||||||
![]() Charlotte 1-5- +12½ -110FanDuel | |||||||
![]() Clemson 3-329% -9½ -110Caesars | |||||||
![]() #3Indiana 6-012% -26½ -113BetRivers | |||||||
Marshall 3-360% +3½ -113BetRivers | |||||||
Ball State 2-4- -1½ -105FanDuel | |||||||
![]() Boise State 4-267% -10½ -110Caesars | |||||||
![]() North Texas 5-150% -5½ -110Caesars | |||||||
![]() #9Georgia 5-130% -6½ -105BetMGM | |||||||
![]() Arkansas 2-471% +7½ -110Caesars | |||||||
![]() Wisconsin 2-482% +27½ -110Caesars | |||||||
Air Force 1-50% -4½ -115FanDuel | |||||||
UAB 2-4100% +21½ -110BetMGM | |||||||
![]() Arizona State 4-293% +10½ -110Caesars | |||||||
Florida 2-4100% -9½ -112BetRivers | |||||||
![]() Louisiana 2-4- +4 -110Caesars | |||||||
![]() #18Virginia 5-10% -17½ -104FanDuel | |||||||
Rutgers 3-3100% +15½ -110BetRivers | |||||||
![]() Georgia Southern 2-40% -6½ -113BetRivers | |||||||
![]() Colorado State 2-4100% +1 -117BetRivers | |||||||
UCLA 2-450% -2½ -118FanDuel | |||||||
Iowa 4-233% -2½ -118FanDuel | |||||||
Kentucky 2-350% +12½ -115BetMGM | |||||||
![]() #19South Florida 5-1- -21½ -110BetMGM | |||||||
Syracuse 3-3- +11½ -110Caesars | |||||||
#13Notre Dame 4-244% -7½ -110FanDuel | |||||||
#6Alabama 5-123% -8 -110Caesars | |||||||
Auburn 3-375% -1½ -110BetRivers | |||||||
Oklahoma State 1-5100% +21½ -112BetRivers | |||||||
#15Brigham Young 6-00% +3½ -120FanDuel | |||||||
![]() New Mexico 3-30% -10 -110BetRivers | |||||||
![]() Oregon State 0-7- - | |||||||
Stanford 2-4- +17½ -110Caesars |
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