BYU Cougars vs Iowa State Cyclones Odds

The upcoming NCAAF game on October 25, 2025, between the BYU Cougars and Iowa State Cyclones at Jack Trice Stadium in Ames, IA, is set to be a thrilling Saturday football matchup. Fans and bettors alike should tune in to FOX to catch all the action live.

Currently, the betting odds favor the Iowa State Cyclones as the favorites with a point spread of -2½ -112, while the BYU Cougars are the underdogs at +2½ -110. The opening odds started at a pick'em PK -110 but have shifted slightly in favor of Iowa State, indicating a growing confidence in the Cyclones' chances. The total over/under is set at 48½, with the over priced at -115 and the under at -106, suggesting a moderately high-scoring game.

Understanding these betting lines is crucial for making an informed wager. The point spread movement shows that bettors are leaning towards Iowa State covering the spread, while the over/under suggests a balanced expectation for scoring. These insights help bettors gauge public sentiment and potential value bets.

For those interested in exploring more NCAAF betting odds, discover all NCAAF odds here. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.