Columbia Lions vs Harvard Crimson Picks

The upcoming Friday football matchup on November 7, 2025, features the Columbia Lions taking on the Harvard Crimson at Robert K. Kraft Field at Lawrence A. Wien Stadium in Manhattan, NY. This NCAAF regular season Week 11 game offers plenty of excitement for fans and bettors alike, airing on ESPN2 and ESPNU. Our expert picks favor Harvard Crimson to win with a predicted score of 28-17, backed by a moneyline prediction. This comes after a strong recent performance by Harvard, winning 6 of their last 10 games and showing a profitable track record in point spread bets with a hit rate near 55% and positive EV. Columbia has struggled more recently, but their underdog status could present value for savvy bettors.

Our analysis suggests that betting on Harvard to cover the spread is the best bet for this game, given their consistent ability to outperform expectations. The Lions' recent games have shown mixed results, but the Crimson's strong home advantage and overall form make them a reliable pick. For those looking to maximize their betting strategy, consider exploring parlays that include Harvard’s moneyline and the total points market.

Fans and bettors can catch all the action on ESPN networks and should check out our full NCAAF picks page for more insights and predictions. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.