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As the Columbia Lions prepare to face the Lafayette Leopards on September 19, 2025, at Fisher Stadium in Easton, PA, fans are gearing up for an exciting Friday football clash. With the game broadcasted on ESPN+, this matchup promises to deliver thrilling moments. The Lions, renowned for their solid pass offense, face a challenge against the Leopards’ formidable pass defense. However, Columbia's quarterback is expected to lead a strategic offensive game, leveraging their recent victories, including a notable win against the Brown Bears. The Lions' defense will need to counter Lafayette's strong rushing game, which has been a significant factor in their recent wins over Georgetown Hoyas and Stonehill Skyhawks. The odds slightly favor Columbia, with a spread of -1.5, suggesting a close contest. With both teams having strong ATS records, bettors should keep an eye on the NCAAF standings page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.