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As we gear up for the Friday football clash on September 19, 2025, between the Columbia Lions and the Lafayette Leopards at Fisher Stadium in Easton, PA, fans and bettors alike are eagerly anticipating the action. This NCAAF showdown is set to be broadcast on ESPN+, offering an exciting opportunity for sports enthusiasts to tune in. Our prediction model, which has a solid track record over the past 10 games, suggests a thrilling game ahead with a predicted score of Columbia 28, Lafayette 17. The Lions are favored to cover the spread, making them a smart pick for bettors looking to capitalize on the odds. With the total set at 45.5, our betting tips lean towards the under, considering the defensive strengths both teams have showcased this season. Our prediction model has been profitable, particularly in the American Total market, with a hit rate of 58% over recent games. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place a wager with a U.S. regulated sportsbook. For more insights and NCAAF picks, check our comprehensive analysis.