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The upcoming clash on September 20, 2025, between the North Carolina State Wolfpack and Duke Blue Devils at Brooks Field at Wallace Wade Stadium in Durham, NC, promises an electrifying start to Week 4 of the 2025-26 NCAAF season. The Blue Devils, playing at home, are poised to leverage their advantage, and the game will be broadcasted on ESPN2. Our prediction model favors Duke with a 67.4% chance of winning and a predicted score of 31-26. The best bet for this game is Duke -2.5, with a hit rate of 59.6% and an EV of 4.2%. Our model has been profitable, winning 6 out of the last 10 games. Check out our NCAAF picks page for more insights. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.