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FINAL
Nov 22, 2025 12:00 PM EST
KU 14 vs ISU 38
Week 13
ISU
-3½ (+100)o55½ (-115)
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Kansas Jayhawks vs Iowa State Cyclones Picks
Updated:Nov 21, 2025 2:47 AM EST
The upcoming NCAAF clash on November 22, 2025, features the Kansas Jayhawks vs Iowa State Cyclones at Jack Trice Stadium in Ames, IA. This Saturday football game is set to be broadcast on Fox Sports 1, making it an exciting event for college football fans and bettors alike.
Our expert picks and betting tips suggest a competitive matchup with a predicted final score of Kansas 29, Iowa State 27. The model favors Kansas with a slight edge on the moneyline and a +3.5 point spread, reflecting a close contest. The predicted total score is around 56, aligning with the over 54.5 market, which has a hit rate just over 51%, indicating a profitable angle for bettors.
In recent games, our prediction model has shown strength in point spread markets, particularly with Iowa State covering at 7.5 points and total points markets trending over 55 with a 60% hit rate. These insights help bettors make informed decisions and find value in their bets.
Don't miss out on this thrilling Saturday football encounter. For more detailed analysis and comprehensive picks for the entire NCAAF season, check out our NCAAF picks page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
UPCOMING GAME PREDICTION
Spread
Money
Total
KUSpread
CONSENSUS LINE
+3 (-109)
PROJECTION
ISU (27) - KU (29)
COVER PROBABILITY
EXPECTED VALUE
+3.8%
BET RATING
SEASON COVER %
4/10
40%
NCAAF
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Top 25
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Div. II & III
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