Kansas Jayhawks vs Iowa State Cyclones Betting Trends

The upcoming Saturday football game on November 22, 2025, between the Iowa State Cyclones and Kansas Jayhawks at Jack Trice Stadium in Ames, IA, promises an exciting NCAAF regular season Week 13 clash. This matchup offers valuable betting trends and game insights for bettors looking to capitalize on the teams' current form and statistical matchups. The Cyclones, favored by 3.5 points with odds of -107 at Caesars, will host the Jayhawks, who are underdogs at +141 odds. The total points line is set at 55.5 with the under favored at -112.

The Cyclones' starting quarterback is expected to lead their offense, which averages 230.3 passing yards and 164.2 rushing yards per game, showcasing a balanced attack. Iowa State's pass offense, with 230.3 yards, will test Kansas's pass defense that allows 207.5 yards on average. On the ground, Iowa State averages 164.2 rushing yards against Kansas's run defense that yields 169.5 yards per game, suggesting a competitive ground battle. Kansas's offense, led by their quarterback, averages 228.9 passing yards and 159.7 rushing yards, facing a Cyclones defense that allows 222.9 passing yards and 149.7 rushing yards. Pass protection and pass rush stats indicate Iowa State has a slight edge in sacks allowed and sacks made, which could influence quarterback performance and betting outcomes.

Recent game stats show Iowa State with a 6-4 straight-up record and a 4-5-1 against the spread (ATS), while Kansas holds a 5-5 straight-up and 4-6 ATS record. The Cyclones' home performance and ATS records can be explored on our NCAAF standings page. Notably, the last matchup on November 9, 2024, saw Kansas defeat Iowa State 45-36, a high-scoring affair that went over the total points line of 52.5, which bettors should consider.

With the game airing on Fox Sports 1, bettors have a great opportunity to watch the action live. The blend of offensive firepower and defensive resilience from both teams makes this game a compelling betting prospect. For those ready to make smart wagering decisions, Start your OddsTrader Turbo subscription or place your bet with a U.S. regulated sportsbook like Caesars to leverage these betting trends and insights.