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Before the game, the Virginia Cavaliers are set to face the Louisville Cardinals on October 4, 2025, in a thrilling NCAAF clash at L&N Federal Credit Union Stadium in Louisville, KY. This Saturday football match is a must-watch, airing on ESPN2. The Louisville Cardinals have the upper hand with a point spread of -6½ -115, indicating their favorite status. Meanwhile, the Virginia Cavaliers are at +6½ -105, making them the underdogs. As bettors eye the odds, it's crucial to understand the dynamics of this game. The current point spread has shifted slightly from the opening odds, reflecting changes in team performances and public sentiment. This matchup not only captivates fans but offers enticing betting lines. Explore more NCAAF odds to make informed wagers. Ready to leverage insights? Start your OddsTrader Turbo subscription today for a competitive edge!
TCU - -6½ -110Bovada | |||||||
![]() Valparaiso - - | |||||||
USC - -35½ -108Heritage | |||||||
![]() Virginia - -3 -110MyBookie | |||||||
![]() North Dakota State - -8½ -105BetOnline | |||||||
Eastern Michigan - -7½ -110Bovada | |||||||
Florida State - -30½ -108Heritage | |||||||
Stanford - -3½ -108Heritage | |||||||
UNLV - -3 -115Bookmaker | |||||||
Rutgers - -30½ -108Heritage | |||||||
![]() Wake Forest - -22½ -108Heritage | |||||||
![]() Kennesaw State - - | |||||||
Buffalo - - | |||||||
![]() Delaware - - | |||||||
UCF - - | |||||||
![]() Georgia Tech - -7 -110BetOnline | |||||||
Minnesota - - | |||||||
![]() Missouri - - | |||||||
Illinois - -27½ -108Heritage | |||||||
![]() Utah - - | |||||||
Eastern Michigan - -3½ -108Heritage | |||||||
Georgia State - - | |||||||
![]() Purdue - - | |||||||
Michigan State - -10½ -105BetOnline | |||||||
![]() Kansas - - | |||||||
USC - -22½ -110BetOnline | |||||||
Stanford - +23 -105BetOnline | |||||||
West Virginia - -17½ -105BetOnline | |||||||
![]() James Madison - -6 -110BetOnline | |||||||
![]() Indiana - -39½ -108Heritage | |||||||
Alabama - -26½ -108Heritage | |||||||
Nebraska - -23½ -105BetOnline | |||||||
![]() Houston - -18½ -108Heritage | |||||||
![]() Connecticut - - | |||||||
Syracuse - - | |||||||
Bowling Green - - | |||||||
Army - - | |||||||
![]() Pittsburgh - -15½ -110Bovada | |||||||
![]() Ohio State - -49½ -110BetOnline | |||||||
![]() South Carolina - -34½ -108Heritage | |||||||
![]() Oklahoma - -40½ -105BetOnline | |||||||
![]() Iowa State - - | |||||||
Kentucky - - | |||||||
Air Force - - | |||||||
Temple - - | |||||||
![]() Georgia - - | |||||||
![]() Cincinnati - -7½ -108Heritage | |||||||
![]() Penn State - -22½ -110BetOnline | |||||||
![]() Duke - -8 -110Bookmaker | |||||||
![]() Texas - -30½ -110BetOnline | |||||||
![]() Oregon - -24½ -108Heritage | |||||||
Auburn - -7 -105Bookmaker | |||||||
Tennessee - - | |||||||
Appalachian State - - | |||||||
![]() Charlotte - - | |||||||
![]() UTSA - - | |||||||
![]() North Dakota State - - | |||||||
Navy - - | |||||||
![]() Tulsa - +12½ -108Heritage | |||||||
Iowa - -30 -110Bookmaker | |||||||
![]() Arkansas - - | |||||||
Southern Miss - - | |||||||
![]() Colorado State - -3½ -108Heritage | |||||||
![]() Old Dominion - - | |||||||
![]() South Florida - -12 -108Heritage | |||||||
Texas A&M - -38½ -110BetOnline | |||||||
Troy - -17 -112Bookmaker | |||||||
![]() Memphis - -10½ -108Heritage | |||||||
![]() South Alabama - - | |||||||
![]() Middle Tennessee - - | |||||||
![]() Kansas State - - | |||||||
![]() Utah State - - | |||||||
![]() Jacksonville State - - | |||||||
![]() Vanderbilt - - | |||||||
![]() Georgia Southern - - | |||||||
![]() Texas Tech - - | |||||||
Rice - - | |||||||
![]() Michigan - -26½ -108Heritage | |||||||
![]() Mississippi State - -28 -110Bookmaker | |||||||
LSU - -11 -110MyBookie | |||||||
Virginia Tech - - | |||||||
![]() Louisiana Tech - - | |||||||
Florida - -26 -110BetOnline | |||||||
![]() Northwestern - - | |||||||
![]() Louisiana - - | |||||||
Maryland - - | |||||||
Brigham Young - - | |||||||
New Mexico State - - | |||||||
![]() Arizona - - | |||||||
San Diego State - - | |||||||
![]() New Mexico - -12 -108Heritage | |||||||
![]() Hawaii - +2½ -110MyBookie | |||||||
![]() Arizona State - - | |||||||
![]() Sacramento State - - | |||||||
![]() California - PK -110BetOnline | |||||||
![]() Nevada - +3½ -115BetOnline | |||||||
![]() Washington - -21½ -108Heritage | |||||||
Notre Dame - -20½ -108Heritage | |||||||
![]() Ole Miss - -4½ -110BetOnline | |||||||
Florida State - +3 -115BetOnline |