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Before the thrilling showdown between the Virginia Cavaliers and the Louisville Cardinals, anticipation is building for the October 4, 2025, clash at the L&N Federal Credit Union Stadium in Louisville, KY. As part of the NCAAF league, this game is set to air on ESPN2, offering fans and bettors an exciting opportunity to dive into some Saturday football action. Our prediction model suggests a close contest, with Louisville edging out a 32-29 victory over Virginia. Given Louisville's strong performance at home, this prediction aligns with their 61.2% win probability. The best bet here is on Virginia +6.5, which boasts a 55.3% coverage likelihood and a positive EV of 4.1%.
Our past predictions have shown a solid hit rate, particularly in the 2way (Including OT) market, where we've been profitable in several recent games. For bettors looking to make the most of this matchup, consider our NCAAF picks for more detailed insights. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook to profit off the edge.
TCU - -6½ -110Bovada | |||||||
![]() Valparaiso - - | |||||||
USC - -35½ -108Heritage | |||||||
![]() Virginia - -3 -110MyBookie | |||||||
![]() North Dakota State - -8½ -105BetOnline | |||||||
Eastern Michigan - -7½ -110Bovada | |||||||
Florida State - -30½ -108Heritage | |||||||
Stanford - -3½ -108Heritage | |||||||
UNLV - -3 -115Bookmaker | |||||||
Rutgers - -30½ -108Heritage | |||||||
![]() Wake Forest - -22½ -108Heritage | |||||||
![]() Kennesaw State - - | |||||||
Buffalo - - | |||||||
![]() Delaware - - | |||||||
UCF - - | |||||||
![]() Georgia Tech - -7 -110BetOnline | |||||||
Minnesota - - | |||||||
![]() Missouri - - | |||||||
Illinois - -27½ -108Heritage | |||||||
![]() Utah - - | |||||||
Eastern Michigan - -3½ -108Heritage | |||||||
Georgia State - - | |||||||
![]() Purdue - - | |||||||
Michigan State - -10½ -105BetOnline | |||||||
![]() Kansas - - | |||||||
USC - -22½ -110BetOnline | |||||||
Stanford - +23 -105BetOnline | |||||||
West Virginia - -17½ -105BetOnline | |||||||
![]() James Madison - -6 -110BetOnline | |||||||
![]() Indiana - -39½ -108Heritage | |||||||
Alabama - -26½ -108Heritage | |||||||
Nebraska - -23½ -105BetOnline | |||||||
![]() Houston - -18½ -108Heritage | |||||||
![]() Connecticut - - | |||||||
Syracuse - - | |||||||
Bowling Green - - | |||||||
Army - - | |||||||
![]() Pittsburgh - -15½ -110Bovada | |||||||
![]() Ohio State - -49½ -110BetOnline | |||||||
![]() South Carolina - -34½ -108Heritage | |||||||
![]() Oklahoma - -40½ -105BetOnline | |||||||
![]() Iowa State - - | |||||||
Kentucky - - | |||||||
Air Force - - | |||||||
Temple - - | |||||||
![]() Georgia - - | |||||||
![]() Cincinnati - -7½ -108Heritage | |||||||
![]() Penn State - -22½ -110BetOnline | |||||||
![]() Duke - -8 -110Bookmaker | |||||||
![]() Texas - -30½ -110BetOnline | |||||||
![]() Oregon - -24½ -108Heritage | |||||||
Auburn - -7 -105Bookmaker | |||||||
Tennessee - - | |||||||
Appalachian State - - | |||||||
![]() Charlotte - - | |||||||
![]() UTSA - - | |||||||
![]() North Dakota State - - | |||||||
Navy - - | |||||||
![]() Tulsa - +12½ -108Heritage | |||||||
Iowa - -30 -110Bookmaker | |||||||
![]() Arkansas - - | |||||||
Southern Miss - - | |||||||
![]() Colorado State - -3½ -108Heritage | |||||||
![]() Old Dominion - - | |||||||
![]() South Florida - -12 -108Heritage | |||||||
Texas A&M - -38½ -110BetOnline | |||||||
Troy - -17 -112Bookmaker | |||||||
![]() Memphis - -10½ -108Heritage | |||||||
![]() South Alabama - - | |||||||
![]() Middle Tennessee - - | |||||||
![]() Kansas State - - | |||||||
![]() Utah State - - | |||||||
![]() Jacksonville State - - | |||||||
![]() Vanderbilt - - | |||||||
![]() Georgia Southern - - | |||||||
![]() Texas Tech - - | |||||||
Rice - - | |||||||
![]() Michigan - -26½ -108Heritage | |||||||
![]() Mississippi State - -28 -110Bookmaker | |||||||
LSU - -11 -110MyBookie | |||||||
Virginia Tech - - | |||||||
![]() Louisiana Tech - - | |||||||
Florida - -26 -110BetOnline | |||||||
![]() Northwestern - - | |||||||
![]() Louisiana - - | |||||||
Maryland - - | |||||||
Brigham Young - - | |||||||
New Mexico State - - | |||||||
![]() Arizona - - | |||||||
San Diego State - - | |||||||
![]() New Mexico - -12 -108Heritage | |||||||
![]() Hawaii - +2½ -110MyBookie | |||||||
![]() Arizona State - - | |||||||
![]() Sacramento State - - | |||||||
![]() California - PK -110BetOnline | |||||||
![]() Nevada - +3½ -115BetOnline | |||||||
![]() Washington - -21½ -108Heritage | |||||||
Notre Dame - -20½ -108Heritage | |||||||
![]() Ole Miss - -4½ -110BetOnline | |||||||
Florida State - +3 -115BetOnline |