Missouri Tigers vs Oklahoma Sooners Odds

The upcoming showdown on November 22, 2025, between the Missouri Tigers and Oklahoma Sooners at Gaylord Family Oklahoma Memorial Stadium in Norman, OK, is set to be a thrilling highlight of the 2025-26 NCAAF season. This Saturday football game promises intense action as both teams vie for supremacy in this REG Week 13 matchup.

Current odds favor the Oklahoma Sooners with a point spread of -5½ -112, slightly shifted from the opening line, indicating strong confidence in the Sooners' home advantage. Meanwhile, the Missouri Tigers hold a +5½ -109 spread, offering an enticing underdog opportunity for bettors. The over/under total is set at 42½ with odds of -115 for the over and -105 for the under, suggesting a moderately high-scoring game.

These betting lines provide valuable insights into the expected competitiveness of the game, helping bettors make informed decisions. Watching this game on ABC and ESPN networks adds to the excitement, making it a perfect chance for fans to engage with the sport and potentially profit.

For those looking to dive deeper into the numbers, our NCAAF odds page offers comprehensive odds and trends. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.