Northwestern Wildcats vs USC Trojans Picks

The upcoming Friday football clash on November 8, 2025, between the Northwestern Wildcats and USC Trojans at Los Angeles Memorial Coliseum in Los Angeles, CA, promises an exciting NCAAF showdown. The game will be broadcast on Fox, providing fans and bettors an excellent opportunity to catch all the action live.

Our picks for this Northwestern Wildcats vs USC Trojans game favor the home team, USC, with a predicted score of 33 to 21. We predict USC will cover the spread at -14, despite Northwestern +14.5 showing a solid 55.3% cover percentage and positive EV of 2.9%. The predicted total score is approximately 53.7 points, with the over 50.5 picks looking strong given the 54.9% coverage and positive EV of 2.5%. These insights come from our well-performing prediction model, which has maintained a high hit rate and EV, especially in the American Total market, winning 6 of the last 10 games.

For bettors seeking smart betting tips and profitable bets, this game offers valuable angles. Our model's success in the total points market and the spread market for USC provides confidence in these picks. To explore more expert NCAAF picks and predictions, check out our expert NCAAF picks and predictions page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.