Syracuse Orange vs Notre Dame Fighting Irish Betting Trends

The upcoming Saturday football showdown on November 22, 2025, between the Syracuse Orange and Notre Dame Fighting Irish at Notre Dame Stadium in South Bend, IN, is a must-watch NCAAF event. This game, airing on NBC, promises exciting betting trends and game insights for sports bettors. Notre Dame enters as the favorite with a -36.5 point spread, while the total points over/under is set at 50.5, reflecting expectations of a high-scoring affair.

Notre Dame boasts a strong offensive lineup averaging 458.2 total yards per game with a balanced attack of 265.7 passing yards and 192.5 rushing yards. Quarterback play is a key factor, with Notre Dame’s starter delivering solid performances and benefiting from excellent pass protection against Syracuse’s pass rush, which averages 22.8 sacks allowed per game. Syracuse, meanwhile, has struggled recently with a 3-7 record but shows resilience in their run game, averaging 117.2 rushing yards and a decent 244.7 passing yards. Their defense, however, is vulnerable, allowing over 430 yards per game on average.

Betting trends indicate Notre Dame’s dominance at home with a 5-1 straight-up home record and a balanced 3-3 ATS home record. Syracuse’s away record is less impressive at 1-4 straight up but slightly better ATS at 3-2. Past meetings, including a decisive 41-24 win for Notre Dame in 2022, suggest a trend favoring the Fighting Irish. The odds spread and total points reflect this, making Notre Dame a smart bet to cover the spread while the over 50.5 points line offers value to those expecting an offensive shootout.

The matchup’s key to watch will be Notre Dame’s passing offense versus Syracuse’s pass defense and how each team manages their run game. Bettors should also consider the impact of injuries and current lineups, which favor Notre Dame’s depth and experience. For a deeper dive into the odds and to optimize your bets, consider Start your OddsTrader Turbo subscription or place your wager with a U.S. regulated sportsbook like Caesars.

In their last matchup on October 29, 2022, Notre Dame defeated Syracuse 41-24, setting the stage for another thrilling encounter this November.