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FINAL
Nov 22, 2025 3:30 PM EST
SYR 7 vs ND 70
Week 13
3-9
Syracuse
7
FINAL
70
10-2
#9 Notre Dame
ND
-36½ (-110)o52 (-105)
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Syracuse Orange vs Notre Dame Fighting Irish Odds

Updated:Nov 22, 2025 1:56 AM EST

The upcoming Saturday football game on November 22, 2025, features an exciting NCAAF matchup between the Syracuse Orange and Notre Dame Fighting Irish at Notre Dame Stadium in South Bend, IN. Fans can catch the action live on NBC. This game offers intriguing odds and betting lines, with Notre Dame favored at -36½ -110 and Syracuse as the underdog at +36½ -109 at Caesars sportsbook. The over/under total is set at 50½, with the over priced at -114 and the under at -107. Opening odds had Notre Dame at -36½ -110 and Syracuse at +36½ -110, showing a slight shift favoring Syracuse, indicating some betting action on the underdog. Understanding these odds and betting lines can help bettors make smarter wagers by spotting value and line movements. Bettors looking to dive deeper should check out the latest NCAAF odds and consider starting an OddsTrader Turbo subscription to gain an edge with real-time data and analytics.

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Spread (FULL GAME)
EXPECTED VALUECOVER PROB.EXPECTED VALUEBEST LINE
team
SyracuseSpread
+7.8%
EV
+7.8%
61%
team
Notre DameSpread
-12.7%
EV
-12.7%
41%
Total (FULL GAME)
BEST LINE
over
OVERTotal
under
UNDERTotal
Spread (1H)
BEST LINE
team
SyracuseSpread
team
Notre DameSpread
MONEYLINE (1H)
BEST LINE
team
SyracuseMONEYLINE
team
Notre DameMONEYLINE
Total (1H)
BEST LINE
over
OVERTotal
under
UNDERTotal
Spread (2H)
BEST LINE
team
SyracuseSpread
team
Notre DameSpread
Total (2H)
BEST LINE
over
OVERTotal
under
UNDERTotal
Spread (1Q)
BEST LINE
team
SyracuseSpread
team
Notre DameSpread
MONEYLINE (1Q)
BEST LINE
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SyracuseMONEYLINE
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Notre DameMONEYLINE
Total (1Q)
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OVERTotal
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UNDERTotal
The best odds available today for Syracuse is +37 -108 at Heritage and for Notre Dame -36½ -110 at BetOnline. The total for the over/under line is o50 -114 at Bet105.
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