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Get ready for an electrifying showdown on September 13, 2025, as the Ohio Bobcats take on the Ohio State Buckeyes at Ohio Stadium in Columbus, OH. This NCAAF clash promises to be a thrilling spectacle, broadcasted live on Peacock. With a history of strong performances, the Buckeyes are looking to dominate on their home turf. Our predictions suggest a close game, with Ohio State favored by a 28.5-point spread. The predicted total score is 51.68, with a slight edge given to the over 49.5 market, which has a 53.3% hit rate and a 1.0% EV. Historically, our picks have been profitable, particularly in American Totals, with a 6-4 record in the last 10 games. This game is a prime opportunity for bettors to capitalize on strategic insights. For more detailed picks, check out our NCAAF picks page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.