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FINAL
Nov 1, 2025 12:00 PM EDT
PSU 14 vs OSU 38
Week 10
OSU
-17½ (-104)o45½ (-107)
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Penn State Nittany Lions vs Ohio State Buckeyes Picks
Updated:Nov 1, 2025 4:01 AM EDT
The upcoming Saturday football clash on November 1, 2025, between the Penn State Nittany Lions and Ohio State Buckeyes at Ohio Stadium in Columbus, OH promises to be an electrifying NCAAF showdown. Broadcasted on Fox, this regular season Week 10 game has bettors buzzing with anticipation. Our expert picks predict a decisive victory for the Ohio State Buckeyes with a predicted score of 35 to 14 over the Nittany Lions, favoring Ohio State on the moneyline with a -19.5 spread. The predicted total score is approximately 49, suggesting an exciting offensive display.
Our prediction model has been profitable in the last 10 games, winning 6 of them in the 2way market, demonstrating a strong hit rate and positive EV. Additionally, the Over 44.5 total market has a 59.7% coverage percentage and an 8.5% EV, making it a high-value betting tip for this game. Bettors can leverage these insights to make smart wagers, capitalizing on trends that have consistently delivered results.
For more detailed NCAAF picks, check out our comprehensive NCAAF picks and predictions. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
UPCOMING GAME PREDICTION
Spread
Money
Total
OSUSpread
CONSENSUS LINE
-18½ (-112)
PROJECTION
OSU (35) - PSU (14)
COVER PROBABILITY
EXPECTED VALUE
+18.8%
BET RATING
SEASON COVER %
6/7
86%
NCAAF
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