Betting Trends: Penn State Nittany Lions vs Ohio State Buckeyes

The upcoming Saturday football game on November 1, 2025, features the Penn State Nittany Lions vs Ohio State Buckeyes at Ohio Stadium in Columbus, OH. This NCAAF regular season Week 10 matchup promises exciting betting trends and game insights for bettors. Ohio State, with a dominant offensive average of 431.4 total yards per game and a strong passing game led by their starting quarterback, faces a Penn State defense allowing 303.7 yards per game. The Buckeyes excel in pass protection and rushing offense, averaging 151.7 rushing yards per game. Meanwhile, Penn State's offense, averaging 355 total yards, will challenge Ohio State's defense that has allowed just 216.9 yards per game. Both teams have shown contrasting ATS records, with Ohio State boasting a 6-0-1 ATS and Penn State struggling at 1-6-0. The point spread currently favors Ohio State by 18.5 points with an over/under of 44.5 points, suggesting a strong Buckeyes win but a potentially low-scoring affair. The game will be broadcast on FOX, providing ample viewing opportunity for fans and bettors alike. Ohio State's recent 34-0 shutout win over Wisconsin and Penn State's narrow 24-25 loss to Iowa highlight their current form. Bettors should consider Ohio State's superior pass rush and Penn State's moderate pass offense when analyzing betting trends. For a smart betting decision, explore the detailed stats and trends and consider starting your OddsTrader Turbo subscription or placing a bet with a U.S. regulated sportsbook. In their last matchup on November 2, 2024, Ohio State edged Penn State 20-13, a closely contested game that could influence this year's betting approach.