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FINAL
Sep 20, 2025 7:00 PM EDT
SIU 59 vs SEMO 31
Week 4
SIU
-5½ (-130)o54½ (-115)
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Southern Illinois vs Southeast Missouri Picks
Updated:Sep 20, 2025 6:23 AM EDT
Before the big clash on September 20, 2025, between the Southern Illinois Salukis and the Southeast Missouri State Redhawks, anticipation is building. This pivotal NCAAF matchup will take place at Houck Field in Cape Girardeau, MO, and promises to deliver thrilling Saturday football action. The Salukis are looking strong with a predicted score of 30 against the Redhawks' 26. Broadcast live on ESPN+, this game is a must-watch for fans and bettors alike. Our picks suggest Southern Illinois will cover the spread at -3.5, while the overall predicted score is expected to exceed the under 54.5 line. Historically, our predictions have shown a high hit rate, particularly with the point spread bets, making this a great opportunity for bettors. Check out our NCAAF picks page for more insights. Ready to take your betting to the next level? Start your OddsTrader Turbo subscription today!
UPCOMING GAME PREDICTION
Spread
Total
SEMOSpread
CONSENSUS LINE
+5½ (100)
PROJECTION
SIU (30) - SEMO (26)
COVER PROBABILITY
EXPECTED VALUE
+2.3%
BET RATING
SEASON COVER %
1/3
33%
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