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The upcoming NFL showdown on December 7, 2025, between the Arizona Cardinals and L.A. Rams at State Farm Stadium in Glendale, AZ, is set to be a thrilling Sunday football event. The Cardinals, currently underdogs with a +9.5 point spread, will face the Rams, favorites to win with a -9.5 spread, on FOX. This game offers valuable betting trends to consider before placing your wagers.
Arizona's offense, led by backup quarterback Jacoby Brissett due to Kyler Murray's season-ending foot injury, will be tested against the Rams' defense, which has been solid but not impenetrable. The Cardinals average 337.25 total yards per game, with a balanced attack of 236.67 passing yards and 100.58 rushing yards, while the Rams boast a slightly higher average of 360.08 total yards with 246.58 passing yards and 113.5 rushing yards. The Rams' defense allows 207.25 passing yards per game, compared to the Cardinals' 219.58 yards allowed, suggesting a close matchup in the air.
The Rams have a notable home advantage and a strong ATS record of 8-4 overall and 4-2 on the road, while the Cardinals struggle with a 6-6 ATS record and a poor 1-5 ATS at home. The total points line is set at 47.5, with the OVER favored at -115 odds, reflecting expectations of a moderately high-scoring game. Betting stats indicate the Rams' pass protection is slightly weaker than the Cardinals' pass rush, which could influence quarterback Matthew Stafford's performance.
Key injuries could impact the game, with the Cardinals missing several defensive starters and the Rams doubtful on cornerback Darious Williams. The Rams' starting quarterback Matthew Stafford is healthy and expected to play, contrasting with the Cardinals' reliance on Brissett.
In their last matchup on December 28, 2024, the Rams edged out the Cardinals 13-9 in a defensive battle at SoFi Stadium, which you can revisit in our detailed analysis. The Cardinals aim to turn the tables this Sunday.
For smart bettors, understanding these betting trends and game insights can provide an edge. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
Minnesota 4-845% +1½ -110Bet365 | |||||||
![]() N.Y. Jets 3-960% +3 -122FanDuel | |||||||
Cleveland 3-920% -3½ -110Bet365 | |||||||
![]() Baltimore 6-635% -5½ -115Caesars | |||||||
![]() Atlanta 4-874% +7 -118BetMGM | |||||||
Jacksonville 8-454% +2 -114SugarHouse | |||||||
![]() Tampa Bay 7-59% -8 -115SugarHouse | |||||||
Buffalo 8-452% -5½ -120FanDuel | |||||||
![]() Las Vegas 2-1088% +8 -110BetMGM | |||||||
Green Bay 8-3-158% -6½ -112BetRivers | |||||||
Arizona 3-985% +10 -115Bet365 | |||||||
![]() Kansas City 6-640% -3½ -114BetRivers | |||||||
![]() L.A. Chargers 8-476% +2½ -105BetMGM | |||||||
Detroit 8-544 -3½ -102BetMGM |
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