Pittsburgh Steelers vs Cincinnati Bengals Betting Trends

The NFL Thursday night football showdown between the Pittsburgh Steelers and the Cincinnati Bengals at Paycor Stadium in Cincinnati, OH, kicks off on October 16, 2025, at 8:15 p.m. ET on Amazon Prime Vid. Get the latest betting trends and odds analysis to guide your bets. The Steelers enter as 5.5-point favorites (-110) over the Bengals (+5.5 at -110) with a total set at 44.5 points (-110). The best spread line for Pittsburgh is -5.5 (-110) at Caesars, while underdogs Cincinnati can be backed at +5.5 (-110) also at Caesars.

Joe Flacco starts under center for the Bengals as Joe Burrow remains on IR, while Pittsburgh hands the reins to Aaron Rodgers. Cincinnati’s passing offense averages 178.5 yards per game against a Steelers defense allowing 245 passing yards. On the ground, the Bengals churn out just 56.7 rushing yards versus Pittsburgh’s 110.6 run allowance. Pittsburgh counters with 84 rushing yards against a Bengals defense surrendering 135.7 rushing yards. Pass protection has been an issue for Cincinnati, allowing 15.7 sacks, versus Pittsburgh’s ferocious rush tally of 25.4 sacks.

Both teams face injury questions: Trey Hendrickson (hip) is listed as questionable but expected to play, and Steelers safety DeShon Elliott (shoulder) is also questionable. The Bengals are 2-4 SU this season, while Pittsburgh boasts a 4-1 mark. You can track their ATS records on our NFL standings page.

In their Jan 4th, 2025 19-17 win, the Bengals edged the Steelers 19–17. Use these game stats to shape your wager and Start your OddsTrader Turbo subscription for real-time odds and advanced analytics.