Nov 30, 2025 1:00 PM EST

Week 13

San Francisco

3-8

Cleveland

-5 (-115)o35½ (-110)

CBS

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49ers vs Browns Picks for November 30 NFL

Updated:Nov 30, 2025 1:19 AM EST

The upcoming NFL showdown on November 30, 2025, features the San Francisco 49ers vs Cleveland Browns at Huntington Bank Field in Cleveland, OH. This Sunday football game will be broadcast on CBS, bringing high stakes and intense competition to fans and bettors alike.

Our expert picks suggest a close contest with the 49ers predicted to win 22-14 against the Browns, covering a spread of San Francisco -5. This prediction is backed by a strong hit rate and positive EV in the 2-way market for San Francisco, which has won 6 out of the last 10 games. Meanwhile, the American total market for under 36 points shows a decent coverage percentage, indicating a likely lower scoring affair.

With both teams showing competitive form, our betting tips focus on the 49ers to cover the spread and the under on total points, offering bettors a smart edge. The game will be held at Huntington Bank Field, a classic outdoor venue that adds to the authentic NFL experience.

For more detailed NFL picks and predictions, check out our comprehensive NFL picks page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

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Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/301:00 PM Houston 6-5 52% +3½ -115BetMGM
Indianapolis 8-3 48% -3 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/301:00 PM Arizona 3-8 74% +3½ -105Bet365
Tampa Bay 6-5 26% -3½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/301:00 PM Jacksonville 7-4 36% -6 -105Bet365
Tennessee 1-10 64% +6½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/301:00 PM L.A. Rams 9-2 33% -10 -115Bet365
Carolina 6-6 67% +10½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/301:00 PM New Orleans 2-9 76% +6 -120BetMGM
Miami 4-7 24% -5 -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/301:00 PM Atlanta 4-7 27% -3 -110BetMGM
N.Y. Jets 2-9 73% +3 -105Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/301:00 PM San Francisco 8-4 58% -5 -110BetMGM
Cleveland 3-8 42% +5½ -105Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/304:05 PM Minnesota 4-7 57% +13 -125BetMGM
Seattle 8-3 43% -10½ -105FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/304:25 PM Buffalo 7-4 29% -3 -112BetRivers
Pittsburgh 6-5 71% +3 -105Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/304:25 PM Las Vegas 2-9 82% +10 -120BetMGM
L.A. Chargers 7-4 18% -9 -114SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/308:20 PM Denver 9-2 47% -6½ -109Caesars
Washington 3-8 53% +6½ -105Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. MON 12/018:15 PM N.Y. Giants 2-10 77% +7½ -115FanDuel
New England 10-2 23% -7 -109Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTHU 11/271:00 PM Green Bay 8-3-1 31 +3 -105BetMGM
Detroit 7-5 24 -3 -105BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTHU 11/274:30 PM Kansas City 6-6 28 -3 -125Bet365
Dallas 6-5-1 31 +3½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTHU 11/278:20 PM Cincinnati 4-8 32 +8 -105BetMGM
Baltimore 6-6 14 -7½ -114BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. FINALFRI 11/283:00 PM Chicago 9-3 24 +7 +100Bet365
Philadelphia 8-4 15 -7 -110BetMGM

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