Dec 21, 2025 1:00 PM EST

Week 16

L.A. Chargers

6-7-1

Dallas

DAL

-2 (-106)o50 (-113)

FOX

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Los Angeles Chargers vs Dallas Cowboys Picks

Updated:Dec 18, 2025 1:49 AM EST

The upcoming NFL regular season Week 16 game on December 21, 2025, features the Los Angeles Chargers visiting the Dallas Cowboys at AT&T Stadium in Arlington, TX. This highly anticipated Sunday football matchup will be broadcasted on FOX, bringing top-tier gridiron action to fans nationwide. Our expert picks and betting tips analyze this clash in depth to help bettors make informed decisions.

The Dallas Cowboys are predicted to edge out the Los Angeles Chargers with a final score of 25-23, with Dallas favored by 2 points on the spread. Our prediction model has been profitable in the last 10 games, particularly with the Under 49.5 points market, boasting a 53.3% hit rate and a positive EV of 2.1%. This suggests a smart betting angle on the total points scored, aligning well with our predicted total score of about 48.4 points.

With the Cowboys playing at home in the retractable dome of AT&T Stadium, their slight spread advantage is supported by recent performance data. The Chargers, while underdogs by 2.5 points, still have a solid chance to cover, making this game a compelling betting opportunity. Fans and bettors can explore more NFL picks and predictions to stay ahead of the curve. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

When is the Los Angeles Chargers vs Dallas Cowboys game?

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ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

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Personalize your notifications and get updates on the teams, players or events you care about most. SAT 12/205:00 PM Philadelphia 9-5 19% -6½ -118BetRivers
Washington 4-10 81% +7 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 12/208:20 PM Green Bay 9-4-1 44% +1½ -105BetMGM
Chicago 10-4 56% -1 -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/211:00 PM Buffalo 10-4 38% -10½ -105Bet365
Cleveland 3-11 62% +10½ -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/211:00 PM N.Y. Jets 3-11 26% +6½ -110Bet365
New Orleans 4-10 74% -5½ -118FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/211:00 PM Minnesota 6-8 36% -2½ -115Bet365
N.Y. Giants 2-12 64% +3 -117BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/211:00 PM Tampa Bay 7-7 29% -3 -105Bet365
Carolina 7-7 71% +3 -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/211:00 PM Kansas City 6-8 19% -2½ -120FanDuel
Tennessee 2-12 81% +3 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/211:00 PM L.A. Chargers 10-4 42% +2½ -112FanDuel
Dallas 6-7-1 58% -1½ -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/211:00 PM Cincinnati 4-10 26% -3½ -114BetRivers
Miami 6-8 74% +4½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/214:05 PM Atlanta 5-9 63% -2½ -120FanDuel
Arizona 3-11 37% +3 -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/214:05 PM Jacksonville 10-4 56% +3½ -110Bet365
Denver 12-2 44% -3½ -102FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/214:25 PM Pittsburgh 8-6 86% +7 -109Caesars
Detroit 8-6 14% -6½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/214:25 PM Las Vegas 2-12 74% +14½ -122FanDuel
Houston 9-5 26% -14 -107Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/218:20 PM New England 11-3 33% +3 -113Caesars
Baltimore 7-7 67% -2½ -121SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. MON 12/228:15 PM San Francisco 10-4 16% -5½ -110Caesars
Indianapolis 8-6 84% +6½ -125BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. FINAL OTTHU 12/188:15 PM L.A. Rams 11-4 37 +2½ -114BetRivers
Seattle 12-3 38 -1 -115SugarHouse

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