Detroit Lions vs Philadelphia Eagles Picks

The upcoming NFL showdown on November 16, 2025, between the Detroit Lions and Philadelphia Eagles at Lincoln Financial Field in Philadelphia, PA, is set to be a thrilling Sunday night football event. This game promises plenty of action and opportunities for bettors looking for sharp picks and insightful betting tips. Both teams bring strong records to the field, with the Lions predicted to edge out the Eagles 25-22, covering the spread of Detroit +3 with a solid 58.3% hit rate and a positive 2.8% EV, making this a smart bet market to consider.

The total points prediction is just over 47, aligning closely with the American Total market's over 46.5 points, which carries a near 50% hit rate. NFL fans can catch the game live on NBC and Peacock, adding to the excitement of this high-stakes match.

Our recent NFL picks have been spot on, especially in point spread markets where we have maintained a profitable streak, winning 6 out of the last 10 games. This strong hit rate and EV in spread betting markets can help bettors make informed decisions and potentially increase their winnings.

For those looking to dive deeper into NFL predictions and parlays, check out our comprehensive league picks page and consider starting your OddsTrader Turbo subscription for an edge in betting. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.