Betting Trends: Los Angeles Chargers vs Jacksonville Jaguars

The upcoming NFL showdown on November 16, 2025, features the Los Angeles Chargers vs Jacksonville Jaguars at EverBank Stadium in Jacksonville, FL. This Sunday football game promises an exciting clash in the 2025-26 season, broadcast on CBS. The Chargers come in as favorites with a -3 point spread and total points set at 43.5, suggesting a moderately high-scoring affair.

Jacksonville's quarterback Trevor Lawrence is set to start, despite some injury concerns among key wide receivers like Brian Thomas (questionable) and the absence of cornerback Jourdan Lewis. The Jaguars' offense, averaging 324.9 yards per game with a balanced attack (204.6 passing yards and 120.3 rushing yards), faces a Chargers defense that allows 280.2 total yards and excels in pass rush with 2.9 sacks per game. The Chargers, led by QB Justin Herbert, boast a strong offense averaging 368.5 yards per game, with a potent passing game of 245.4 yards and a solid running game. However, they face injury setbacks on their offensive line and wide receiver Quentin Johnston (questionable but likely to play).

Betting trends favor the Chargers slightly, but Jacksonville's home record and recent performances make this a competitive matchup. The Jaguars have a 3-2 home ATS record, while the Chargers are 1-3 ATS on the road. Recent games show the Jaguars scoring around 20-30 points and the Chargers typically scoring 20-30 points as well, indicating a balanced scoring potential.

With a spread of Chargers -3 and total points at 43.5, bettors should consider the strong offensive output and defensive capabilities on both sides. The Chargers' pass offense vs Jaguars' pass defense and Jaguars' run offense vs Chargers' run defense will be key to watch. For more detailed betting insights and to make smarter wagers, check out our Start your OddsTrader Turbo subscription or place your bet with a U.S. regulated sportsbook.

In their last matchup on January 14, 2023, where the Jaguars edged out the Chargers 31-30, both teams showed a close contest, setting the stage for another thrilling encounter.