Get the latest injury news for the San Francisco 49ers. NFL injuries can have a huge impact on betting odds, so keeping up-to-date with which players on the team are injured, what their injuries are and projected recovery times can help you to make more informed wagers.
Sam Okuayinonu
91 Defensive Line
3 hours ago
Questionable
Est. Return Nov 30, 2025
Okuayinonu (ankle) is questionable to return to Monday's game against Carolina, Matt Barrows of The Athletic reports. More Details
Brandon Aiyuk
11 Wide Receiver
2 days ago
PUP
Est. Return Dec 14, 2025
The 49ers remain committed to getting Aiyuk (knee) "healthy and back on the field" in 2025, even though the team had approximately $27 million in guarantees for the 2026 season voided in his contract, Mike Garafolo of NFL Network reports. More Details
Eddy Pineiro
18 Kicker
2 days ago
INACTIVE
Est. Return Nov 30, 2025
Pineiro (hamstring) has been ruled out for Monday's game against the Panthers, Cam Inman of The San Jose Mercury News reports. More Details
Tatum Bethune
48 Linebacker
2 days ago
INACTIVE
Est. Return Nov 30, 2025
Bethune (ankle) has been ruled out for Monday's game against Carolina, Cam Inman of The San Jose Mercury News reports. More Details
Trent Taylor
81 Wide Receiver
6 months ago
Injury Reserve
Est. Return Feb 9, 2026
The 49ers placed Taylor (undisclosed) on injured reserve Tuesday. More Details
Kevin Givens
90 Defensive Line
a month ago
INACTIVE
Est. Return Nov 30, 2025
The 49ers reinstated Givens (pectoral) from injured reserve Saturday. More Details
Fred Warner
54 Linebacker
a month ago
Injury Reserve
Est. Return Feb 9, 2026
The 49ers placed Warner (ankle) on injured reserve Saturday. More Details
Nick Bosa
97 Defensive Line
2 months ago
Injury Reserve
Est. Return Feb 9, 2026
Bosa (knee) underwent surgery to address his torn ACL on Friday, Cam Inman of The San Jose Mercury News reports. More Details
Yetur Gross-Matos
94 Defensive Line
23 days ago
Injury Reserve
Est. Return Nov 30, 2025
Gross-Matos (knee) was placed on injured reserve Saturday. More Details
Patrick Taylor Jr.
32 Running Back
3 months ago
Injury Reserve
Est. Return Feb 9, 2026
Taylor will undergo season-ending surgery to repair a fracture in his shoulder, Nick Wagoner of ESPN.com reports. More Details
Tre Tomlinson
35 Cornerback
6 months ago
Injury Reserve
Est. Return Feb 9, 2026
Tomlinson (undisclosed) reverted to the 49ers' injured reserve Tuesday, per the NFL's transaction log. More Details
Robert Beal Jr.
51 Defensive Line
6 hours ago
INACTIVE
Est. Return Nov 30, 2025
Beal (concussion) is inactive for Monday's game against the Panthers, Briana Jeannel of the 49ers' official site reports. More Details
Jacob Cowing
19 Wide Receiver
7 days ago
Injury Reserve
Est. Return Dec 14, 2025
Coach Kyle Shanahan said Monday that Cowing's (hamstring) 21-day practice window will likely be opened following the 49ers' Week 14 bye, Matt Maiocco of NBC Sports Bay Area reports. More Details
Mykel Williams
98 Defensive Line
16 days ago
Injury Reserve
Est. Return Feb 9, 2026
The 49ers placed Williams (knee) on injured reserve Saturday. More Details
Jakob Robinson
49 Cornerback
3 months ago
Injury Reserve
Est. Return Feb 9, 2026
Robinson (forearm) was placed on injured reserve Tuesday. More Details
Kurtis Rourke
4 Quarterback
3 months ago
NFI-R
Est. Return Dec 14, 2025
Rourke (knee) was placed on the reserve/non-football injury list Tuesday. More Details
Jordan Watkins
17 Wide Receiver
6 hours ago
INACTIVE
Est. Return Nov 30, 2025
Watkins (coach's decision) is inactive for Monday's game against the Panthers, Briana Jeannel of the 49ers' official site reports. More Details
Jordan James
29 Running Back
6 hours ago
INACTIVE
Est. Return Nov 30, 2025
James (coach's decision) is inactive for Monday's game against the Panthers, Briana Jeannel of the 49ers' official site reports. More Details
Tarron Jackson
56 Defensive Line
4 months ago
Injury Reserve
Est. Return Feb 9, 2026
The 49ers placed Jackson (undisclosed) on injured reserve Tuesday. More Details
Connor Colby
75 Offensive Line
2 months ago
INACTIVE
Est. Return Nov 30, 2025
Colby (groin) is listed as questionable for Sunday's game against the Cardinals, Briana Jeannel of the 49ers' official site reports. More Details