Ottawa Senators vs Buffalo Sabres Betting Trends

The Ottawa Senators vs Buffalo Sabres at KeyBank Center in Buffalo, NY, on October 15, 2025, in the NHL, airs on MSG-B and ESPN+ at 7:00 PM ET. The Buffalo Sabres have struggled out of the gate, scoring just 0.67 goals per game while allowing 2.67 this season. Ottawa Senators average 2.67 goals for and concede 4.00 per contest. Both teams convert roughly 3.67 power play opportunities per game and kill 75% of opponent man advantages. These special teams numbers set the stage for compelling game insights and should factor heavily into your wagering decisions.

Buffalo has no major injury concerns and is expected to start Eric Comrie, who has recorded 30.33 saves per game early on. Ottawa counters with Joonas Korpisalo, posting 21.33 saves on average. In their Sabres 5-2 win on April 1, Buffalo topped Ottawa by a 5-2 score. Both teams will look to reverse recent trends against each other.

Oddsmakers list the Senators as -125 moneyline favorites with Caesars, while the Sabres sit at +105 at the same book. The spread is Ottawa -1.5 (+205) and Buffalo +1.5 (-250). The total is set at 6 goals with Under/Over both -110. Buffalo is 0-2 ATS at home while Ottawa is 1-1 on the road, as shown on our NHL standings page. For those targeting goals, Under 6 goals (-110) at Caesars is our top play given recent defensive showings. Ready to bet smarter? Start your OddsTrader Turbo subscription or place your wager with a U.S. regulated sportsbook to capitalize on these betting trends.