We’ve reached the halfway point of the 2025 regular season, and things are working out pretty much as expected – but not for everyone. The Baltimore Ravens, for example, are in danger of missing the playoffs at 3-5 after checking in as +700 preseason Super Bowl LX co-favorites. Meanwhile, the Seattle Seahawks (+6000) and New England Patriots (+8000) lead their respective divisions. Will they end up meeting again in Santa Clara?
First things first. Let’s take a closer look at the live NFL odds Week 10. This week 10 is stacked with competitive matchups that could flip the balance of power in both conferences.
NFL Odds Week 10 At-a-Glance
Alas, this week’s football betting lines don’t include Kansas City or Dallas – they both have the bye, as do Cincinnati and Tennessee. But that just makes the remaining games even more competitive, especially when it comes to our featured contests for Week 10. Let’s take a look.
New England Patriots vs. Tampa Bay Buccaneers (TB -2.5)
Sunday, November 9 – 1:00 PM EST
Are these Patriots (7-2 SU, 6-3 ATS) the real deal? Maybe not; they’ve played the softest schedule in the entire league, according to Pro Football Reference. The Buccaneers (6-2 SU, 5-3 ATS), on the other hand, have been properly battle-tested. Tampa might be the sharp side here at -2.5 despite their plus-19 point differential being substantially lower than New England’s plus-68.
Having said that, early reports do suggest some big money has landed on the Bucs – but not sharp money. The wiseguys seem more inclined to pound Over 48.5, although not enough to budge the football odds from their opening total as we go to press.
Pittsburgh Steelers vs. Los Angeles Chargers (LAC -3)
Sunday, November 9 – 8:20 PM EST
Miracle of miracles, Pittsburgh (5-3 SU, 4-4 ATS) is still on top of the AFC North despite multiple injuries on defense and QB Aaron Rodgers turning 42 next month. Rodgers (52.7 QBR) has been okay; both the Steelers and Chargers (6-3 SU, 3-5-1 ATS) have benefitted from easier schedules, but L.A. does look like the better team at plus-22 in point differential compared to Pittsburgh at plus-7.
Getting the full three points appears to be enough for the sharps to take the underdog Steelers here – and for significant money as well. Big moneyline bets are also coming in on Pittsburgh +130, but not from the sharps, who have been more inclined to hit Under 45.5 for value. That total has dipped to 45 or even 44.5 in early betting at most online sportsbooks.
Philadelphia Eagles vs. Green Bay Packers (GB -2.5)
Monday, November 10 – 8:15 PM EST
Is this week’s edition of Monday Night Football a preview of the NFC Championship Game? Perhaps; the defending champion Eagles (6-2 SU, 5-3 ATS) are the only winning team in the NFC East, while the Packers (5-2-1 SU, 3-5 ATS) remain on top of the NFC North despite losing to Carolina (+13.5 away) in Week 9.
Never overreact to recent results. The big money is landing on Philadelphia thus far, both at +2.5 on the spread and +120 on the moneyline, but our sources tell us this isn’t sharp action. The pros are more interested in the Under again at 44.5 points, down from 45 at the open on what should be a chilly November evening at Lambeau Field – possibly after a light dusting of snow over the weekend.
Place Your Week 10 Bets Now!
If you want to squeeze the most value out of the NFL odds week 10, this week has five additional games where the point spread is less than four at press time; this is where you need to pay close attention to both the spreads and moneylines to see which offers the better return.
Watch out for changes in vigorish as well when you’re surfing the live NFL lines at OddsTrader – the more betting accounts you have, the more likely you’ll get the best price on the board.
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Try it free for 30 days, and kick the tires by entering any question you have about this week’s featured games into our exclusive BetStation chatbot. Knowledge is power; put OddsTrader Turbo to good use, and make sure to check in again soon for our full slate of Week 10 NFL picks.
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*The line and/or odds referenced in this article might have changed since the content was published. For the latest information on line movements, visit OddsTrader’s free betting odds tool.