The CFP seedings are starting to take shape, and below we discuss our college football picks Week 10, the marquee matchups on Saturday that have everyone from average fans to expert handicappers talking about these pivotal matchups.
We have three of our best bets below, and last week we had our first bumpy Saturday as UCLA +24 ½ got blown out by the Cinderella story of the 2025 college football season, the Indiana Hoosiers, who made short work of the Bruins in a 56-6 shellacking.
We followed that up with a push as Texas -7 got the W in a 45-38 overtime decision, while LSU +2 ½ came up short against Texas A&M in a 49-25 loss.
Without further ado, let’s redeem ourselves and go three for three in our college football predictions in Week 10.
NCAAF Picks Week 10 At-A-Glance
We take immense pride in our college football picks for Week 10, and once the research is done and we have focused on those games that give us the best chance of success, we then go shopping for the sharpest lines.
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This week, our best college football picks for Week 10 are as follows:
- Vanderbilt +2 ½
- Penn State +21
- Tennessee -3 ½
Let’s start with the Vanderbilt-Texas matchup and determine the best value for this week.
Vanderbilt Commodores vs. Texas Longhorns (-2½)
Saturday, November 01, 2025 – 12:00 PM EDT
There are two Cinderella stories this season, and one is a school known for its legendary Hoosiers’ basketball program, while the other is a perennial SEC laughingstock, Vanderbilt.
But the Commodores have a gritty gunslinger under center in Diego Pavia, who has guided this group to a 7-1 record and a No. 9 ranking. We should also note that Vandy has covered in six of those eight contests this season, including a 17-10 decision over Missouri as a three-point home underdog.
On the flip side, Arch Manning came into the season with Heisman hopes and a national championship goal in his sights.
Unfortunately, neither has manifested, as Manning has looked dazed and confused for stretches this season, and the Horns have tumbled from a lofty No. 1 preseason ranking to No. 20 as they enter this one with a 6-2 mark.
We should also note that Texas has covered in only two of those eight games this season.
The betting lines have Vandy winning this one outright, 25-22, and I agree. The oddsmakers have the wrong favorite, as Vanderbilt is poised to pull a mild upset in this one.
Consider that last year, when these teams met, the talent disparity was vast, as reflected by Texas being installed as a 17-point favorite. However, Texas eked out a 20-17 win, but this year the teams are much more even, and the score will be reversed.
Expert Pick: Vanderbilt +2½ (-110) at Caesars
Penn State vs. Ohio State (-20½)
Saturday, November 01, 2025 – 12:00 PM EDT
When the preseason rankings came out, Penn State was No. 2 in the nation. That seems like forever ago, but for a short while, it appeared as though Penn State was prepared to return to its glory days. They won their first three games but failed to cover in all of them.
And then the boom came down fast and furious, as the Nittany Lions dropped their next four games and now enter what was expected to be a national championship preview with a 3-4 record and a 1-6 ATS mark.
Penn State fired its head coach a few weeks ago, and quarterback Drew Allar has not had great protection. And although the Buckeyes have been a house of fire this season, the public tends to get overhyped about these juggernauts, and that is exactly what’s happened here.
I have no doubt Ohio State will win this game, but the oddsmakers are inflating this line, anticipating a slew of public money on the Buckeyes. If you want to give me a nearly three-touchdown head start with PSU, then who am I to refuse?
Expert Pick: Penn State +20½ (-110) at Caesars
Oklahoma vs. Tennessee (-3½)
Saturday, November 01, 2025 – 07:30 PM EDT
The SEC takes center stage for this Saturday night showdown between a pair of 6-2 conference foes.
Oklahoma is 3-4 against the number and suffered a 34-26 loss to No. 8 Ole Miss last week as 5 ½ point home chalk, while Tennessee rebounded from a loss to Alabama with an impressive 56-34 win over Kentucky, easily covering as 7 ½ point road favorites.
This week, we see that the Sooners have to hit the road and play an excellent team at a very hostile venue.
You may recall that the Vols visited Oklahoma last year and came away with a double-digit win as 5 ½ point road chalk. I believe we will see a similar result because Tennessee has an electric offense, averaging 45.6 points per game (2nd), while Oklahoma does not (73rd, averaging 28.4 PPG).
Let’s lay it and like it with the Vols.
Expert Pick: Tennessee -3 ½ (-110) at BetMGM
Place Your Week 10 Picks & How to Bet Smart This Week
My college football picks Week 10, posted today for Vanderbilt vs. Texas, Penn State vs. Ohio State, and Oklahoma vs. Tennessee, will not remain stagnant forever. Odds, point spreads, and totals are dynamic, which means the moneylines and point spreads you see here may not be around by gametime.
Therefore, it is important that you get the sharpest line available, and the only way to do that is to get down immediately on the games and make sure you have an active account.
That’s right, make certain your account is funded, and perhaps get accounts at two or more sportsbooks so you can compare the numbers. Make sure to get down at a place you trust and at the best lines or odds available.
While you’re at it, make sure to download the free-to-use OddsTrader App available for iOS and Android phones for odds, picks, and props anywhere at any time!
Speaking of which, you can always check out these and other NCAAF picks Week 10 on OddsTrader.
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More Expert Picks
Check out Jefe Picks’ top picks for this week below. And remember to visit our YouTube channel for more daily betting advice!
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