Betting Trends: St. Louis Vs CH Cubs Cubs

Before the game on September 28, 2025, the St. Louis Cardinals are set to face off against the Chicago Cubs at Wrigley Field in Chicago, IL, as part of the MLB regular season. This matchup promises excitement as both teams bring their own strengths to the field. The Cardinals are looking to bounce back after a loss in their last encounter with the Cubs, where they fell 3-7. The game will air on FDSMW, and fans can look forward to watching RHP Javier Assad take the mound for the Cubs, boasting a 4.263 ERA. Meanwhile, the Cardinals will counter with RHP Kyle Leahy, who holds a 3.176 ERA.

Betting trends indicate a slight edge for the Cubs, who are favored with -170 odds at Caesars, while the Cardinals stand at +143. Historically, the Cubs have shown strong offensive capabilities, with players like Ian Happ and Seiya Suzuki contributing significantly. For the Cardinals, Nolan Arenado's performance will be crucial as he aims to drive their offense. The over/under is set at 9.5, and given both teams' recent performances, bettors might lean towards the over.

In terms of betting insights, the Cubs have a better record at home, standing 49-31, compared to the Cardinals' away record of 34-46. These statistics, along with the starting pitchers' performances, suggest a potentially high-scoring game. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook. For more detailed analysis, check out our MLB standings page.